Calcitonin Receptor antibody

Rabbit anti Rat Calcitonin Receptor

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
Calcitonin Receptor

Product Code Applications Pack Size List Price Your Price Qty
AHP635
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C E IF P * WB 0.1 mg loader
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AHP635T
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SDS Safety Datasheet SDS
C E IF P * 10 µg loader
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Search for Batch Specific Datasheets

Rabbit anti Rat Calcitonin Receptor antibody recognizes the calcitonin receptor in human, mouse and rat. The calcitonin receptor is a seven transmembrane domain cell surface protein which is coupled to G protein messenger systems. Rabbit anti Rat Calcitonin Receptor antibody recognizes an epitope within the cytoplasmic domain that is common to both C1a and C1b rat isoforms.

Calcitonin receptor is expressed in kidney, central and peripheral nervous systems and in osteoclasts. It is also expressed in a number of tissues during the development of the embryo and may be important in foetal morphogenesis.

Target Species
Rat
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Human
Fish
Atlantic Stingray
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to calcitonin receptor were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography on Protein A.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
<0.1% Sodium Azide (NaN3)
Immunogen
Synthetic peptide derived from a C-terminal sequence of rat calcitonin receptor.
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 1/100,000
Immunofluorescence
Immunohistology - Frozen 1/10 1/500 Pack Size: 0.1 mg
1/50 Pack Size: 10 µg
Immunohistology - Paraffin 1 1/1000 Pack Size: 0.1 mg
1/10 Pack Size: 10 µg
1/5000 Pack Size: 0.1 mg
1/50 Pack Size: 10 µg
Western Blotting Reducing conditions
  1. 1The use of 4% paraformaldehyde fixation, rather than formalin fixation is recommended.

    A sensitive detection system is also recommended. e.g. A catalysed signal amplification system.
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Kidney, cultured osteoclasts

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References for Calcitonin Receptor antibody

  1. Kovacs, C.S. et al. (2002) Calcitropic gene expression suggests a role for the intraplacental yolk sac in maternal-fetal calcium exchange.
    Am J Physiol Endocrinol Metab. 282 (3): E721-32.
  2. Wookey, P.J. et al. (2008) Calcitonin receptor immunoreactivity associated with specific cell types in diseased radial and internal mammary arteries.
    Histopathology. 52 (5): 605-12.
  3. Tolcos, M. et al. (2003) Ontogeny of calcitonin receptor mRNA and protein in the developing central nervous system of the rat.
    J Comp Neurol. 456 (1): 29-38.
  4. Tikellis, C. et al. (2003) Calcitonin receptor isoforms expressed in the developing rat kidney.
    Kidney Int. 63: 416-26.
  5. Gnocchi, V.F. et al. (2009) Further characterisation of the molecular signature of quiescent and activated mouse muscle satellite cells.
    PLoS One. 4(4):e5205.
  6. Becskei, C. et al. (2004) Immunohistochemical mapping of calcitonin receptors in the adult rat brain.
    Brain Res. 1030: 221-33.
  7. Gooi, J.H. et al. (2010) Calcitonin impairs the anabolic effect of PTH in young rats and stimulates expression of sclerostin by osteocytes.
    Bone. 46: 1486-97.
  8. Gelsleichter, J.J. (2006) MCAA: Development of laboratory skills in molecular biology to examine patterns of calcitonin and calcitonin receptor gene expression in cartilaginous fishes.
    Mote technical report 1392.
  9. View The Latest Product References
  10. Wookey, P.J. et al. (2012) Transient expression of the calcitonin receptor by enteric neurons of the embryonic and early post-natal mouse.
    Cell Tissue Res. 347: 311-7.
  11. Mourikis, P. et al. (2012) Cell-autonomous Notch activity maintains the temporal specification potential of skeletal muscle stem cells.
    Development. 139: 4536-48.
  12. Park, J.K. et al. (2012) Increased generation of TRAP expressing multinucleated giant cells in patients with granulomatosis with polyangiitis.
    PLoS One. 7: e42659.
  13. Le Roux, I. et al. (2015) Numb is required to prevent p53-dependent senescence following skeletal muscle injury.
    Nat Commun. 6: 8528.
  14. Almeida, C.F. et al. (2016) Muscle Satellite Cells: Exploring the Basic Biology to Rule Them.
    Stem Cells Int. 2016: 1078686.
  15. Yamaguchi, M. et al. (2015) Calcitonin Receptor Signaling Inhibits Muscle Stem Cells from Escaping the Quiescent State and the Niche.
    Cell Rep. 13 (2): 302-14.
  16. Wookey, P.J. (2009) A Review of Calcitonin Receptor Expression in Embryonic, Foetal and Adult Tissues, with an Hypothesis on the Connection Between Expression During Foetal Development and Disease
    The Open Zoology Journal 2: 53-61.

Immunohistology - Paraffin

Western Blotting

RRID
AB_2068967
UniProt
P32214
Entrez Gene
Calcr
GO Terms
GO:0005886 plasma membrane
GO:0016021 integral to membrane
GO:0004948 calcitonin receptor activity
GO:0030424 axon
GO:0032841 calcitonin binding
GO:0043025 neuronal cell body
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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