Tryptophan Hydroxylase antibody
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Sheep anti Rabbit Tryptophan Hydroxylase
- Product Type
- Polyclonal Antibody
- Polyclonal IgG
- Tryptophan Hydroxylase
|Sheep anti Rabbit tryptophan hydroxylase antibody recognizes tryptophan hydroxylase, also known as Tryptophan 5-hydroxylase 1 or Tryptophan 5-monooxygenase 1. Tryptophan hydroxylase is a 444 amino acid ~55 kDa enzyme involved in the synthesis of the neurotransmitter serotonin.|
- Target Species
- Species Cross-Reactivity
Target Species Cross Reactivity Rat Human Mammals Expected from Sequence
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified Ig - liquid
- Purified Ig prepared by affinity chromatography
- Buffer Solution
- HEPES buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
0.01% Bovine Serum Albumin
- Recombinant rabbit tryptophan hydroxylase, isolated as inclusion bodies from E. coli and purified by preparative SDS-PAGE.
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
- 9260-2505 has been used for immunohistochemistry on formaldehyde fixed tissue, it is useful for cell body but not fiber staining
|Description||Product Code||Applications||Pack Size||List Price||Your Price||Quantity|
|Rabbit anti Sheep IgG (H/L):Biotin||5184-2304||C E F WB||1.5 ml||Log in|
|List Price||Your Price|
|Description||Rabbit anti Sheep IgG (H/L):Biotin|
References for Tryptophan Hydroxylase antibody
Lowry, C.A. et al. (2000) Corticotropin-releasing factor increases in vitro firing rates of serotonergic neurons in the rat dorsal raphe nucleus: evidence for activation of a topographically organized mesolimbocortical serotonergic system.
J Neurosci. 20 (20): 7728-36.
Federici, L.M. et al. (2016) Hypothalamic orexin's role in exacerbated cutaneous vasodilation responses to an anxiogenic stimulus in a surgical menopause model.
Psychoneuroendocrinology. 65: 127-37.
Johnson, P.L. et al. (2005) Acute hypercarbic gas exposure reveals functionally distinct subpopulations of serotonergic neurons in rats.
J Psychopharmacol. 19 (4): 327-41.
Sajdyk, T.J. et al. (2008) Neuropeptide Y in the amygdala induces long-term resilience to stress-induced reductions in social responses but not hypothalamic-adrenal-pituitary axis activity or hyperthermia.
J Neurosci. 28 (4): 893-903.
Johnson, P. et al. (2008) Disruption of GABAergic tone in the dorsomedial hypothalamus attenuates responses in a subset of serotonergic neurons in the dorsal raphe nucleus following lactate-induced panic.
J Psychopharmacol. 22 (6): 642-52.
Yu B et al. (2015) Mechanisms Underlying Footshock and Psychological Stress-Induced Abrupt Awakening From Posttraumatic "Nightmares".
Int J Neuropsychopharmacol. Nov 20. pii: pyv113. [Epub ahead of print]
Abrams, J.K. et al. (2005) Serotonergic systems associated with arousal and vigilance behaviors following administration of anxiogenic drugs.
Neuroscience. 133 (4): 983-97.
Staub, D.R. et al. (2005) Urocortin 2 increases c-Fos expression in topographically organized subpopulations of serotonergic neurons in the rat dorsal raphe nucleus.
Brain Res. 1044 (2): 176-89.
View The Latest Product References
Cui, S.Y. et al. (2011) Diltiazem potentiates pentobarbital-induced hypnosis via 5-HT1A and 5-HT2A/2C receptors: role for dorsal raphe nucleus.
Pharmacol Biochem Behav. 99 (4): 566-72.
Bouwknecht, J.A. et al. (2007) Differential effects of exposure to low-light or high-light open-field on anxiety-related behaviors: relationship to c-Fos expression in serotonergic and non-serotonergic neurons in the dorsal raphe nucleus.
Brain Res Bull. 72 (1): 32-43.
Gardner, K.L. et al. (2005) Early life experience alters behavior during social defeat: focus on serotonergic systems.
Neuroscience. 136 (1): 181-91.
Hale, M.W. et al. (2008) Exposure to an open-field arena increases c-Fos expression in a subpopulation of neurons in the dorsal raphe nucleus, including neurons projecting to the basolateral amygdaloid complex.
Neuroscience. 157 (4): 733-48.
Spiga, F. et al. (2006) Injections of urocortin 1 into the basolateral amygdala induce anxiety-like behavior and c-Fos expression in brainstem serotonergic neurons.
Neuroscience. 138 (4): 1265-76.
Rook, G. et al. (2003) Treatment of conditions of the central nervous system using mycobacteria
U.S. Patent Publication US20030170275 A1
Staub, D.R. et al. (2006) Evidence supporting a role for corticotropin-releasing factor type 2 (CRF2) receptors in the regulation of subpopulations of serotonergic neurons.
Brain Res. 1070 (1): 77-89.
Lowry, C.A. et al. (2007) Identification of an immune-responsive mesolimbocortical serotonergic system: potential role in regulation of emotional behavior.
Neuroscience. 146 (2): 756-72.
- GO Terms
- GO:0004510 tryptophan 5-monooxygenase activity
- GO:0005506 iron ion binding
- GO:0055114 oxidation-reduction process
- GO:0009072 aromatic amino acid family metabolic process
- GO:0016597 amino acid binding
- GO:0042427 serotonin biosynthetic process
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