Goat anti mouse osteocalcin antibody is specific for intact osteocalcin and recognizes a site at the carboxyl terminal.Osteocalcin (Bone Gla Protein) is a 49 amino acid single chain vitamin K dependent protein (MW 5.8 kDa), made by osteoblasts that is a major component of the non-collagenous bone matrix. Serum osteocalcin is elevated in diseases characterized by increased bone turnover such as osteoporosis, hyperparathyroidism and Paget’s disease, and low in conditions associated with low bone turnover such as hypoparathyroidism and growth hormone deficiency.
- Target Species
- Species Cross-Reactivity
Target Species Cross Reactivity Rat Human Bovine Monkey Elk Chicken
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Serum - liquid
- Preservative Stabilisers
0.1% Sodium Azide (NaN3)
- Highly purified native mouse osteocalcin.
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- Shelf Life
- 18 months from date of despatch.
- P86547 Related reagents
- Entrez Gene
- Bglap2 Related reagents
- GO Terms
- GO:0005509 calcium ion binding
- GO:0005615 extracellular space
- GO:0030500 regulation of bone mineralization
- GO:0031016 pancreas development
- GO:0031214 biomineral tissue development
- GO:0032024 positive regulation of insulin secretion
- GO:0032869 cellular response to insulin stimulus
- GO:0042593 glucose homeostasis
- GO:0044242 cellular lipid catabolic process
- GO:0044342 type B pancreatic cell proliferation
- GO:0046848 hydroxyapatite binding
- For research purposes only
Applications of Osteocalcin antibody
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen||1/50||1/500|
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
Copyright © 2018 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
|Description||Product Code||Pack Size||Applications||List Price||Quantity|
|Rabbit anti Goat IgG (Fc):FITC||STAR122F||1 mg||F|
|Rabbit anti Goat IgG (Fc):HRP||STAR122P||1 mg||C E WB|
Product Specific References
References for Osteocalcin antibody
Gundberg, C. M. et al. (1992) Development and validation of a radioimmunoassay for mouse osteocalcin: paradoxical response in the Hyp mouse.
Matsumoto, T. et al. (2010) Lnk-dependent axis of SCF-cKit signal for osteogenesis in bone fracture healing.
J Exp Med. 207: 2207-23.
Davies, M.R. et al. (2003) BMP-7 is an efficacious treatment of vascular calcification in a murine model of atherosclerosis and chronic renal failure.
J Am Soc Nephrol. 14 (6): 1559-67.
Tasso, R. et al. (2009) Recruitment of a host's osteoprogenitor cells using exogenous mesenchymal stem cells seeded on porous ceramic.
Tissue Eng Part A. 15: 2203-12.
Qian, H. et al. (2013) Molecular characterization of prospectively isolated multipotent mesenchymal progenitors provides new insight into the cellular identity of mesenchymal stem cells in mouse bone marrow.
Mol Cell Biol. 33: 661-77.
Cherry, H.M. et al. (2014) In vivo phenotypic characterisation of nucleoside label-retaining cells in mouse periosteum.
Eur Cell Mater. 27: 185-95; discussion 195.
Ma, M.S. et al. (2016) Characterization and comparison of osteoblasts derived from mouse embryonic stem cells and induced pluripotent stem cells.
J Bone Miner Metab. Jan 8. [Epub ahead of print]
Sista S et al. (2011) The influence of surface energy of titanium-zirconium alloy on osteoblast cell functions in vitro.
J Biomed Mater Res A. 97 (1): 27-36.