Notch 1 antibody
Rabbit anti Notch 1 antibody recognizes neurogenic locus notch homolog protein 1 (Notch 1). Notch (DSL) proteins are a family of transmembrane proteins with repeated extracellular EGF domains and the notch (or DSL) domains. These proteins are involved in inhibition in embryogenesis. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells. It is a protein which functions as a receptor for membrane bound ligands and the Notch family members play a role in a variety of developmental processes by controlling cell apoptosis.
Product Details
- Target Species
- Mouse
- Species Cross-Reactivity
-
Target Species Cross Reactivity Human Rat Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 30% Glycerol
0.5% Bovine Serum Albumin
0.01% Thiomersal - Immunogen
- Synthetic peptide corresponding to residues surrounding amino acid 1760 of mouse Notch 1
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
Storage Information
- Storage
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- Q01705
- Entrez Gene
- Notch1
- GO Terms
- GO:0005515 protein binding
- GO:0005509 calcium ion binding
- GO:0001701 in utero embryonic development
- GO:0001708 cell fate specification
- GO:0001837 epithelial to mesenchymal transition
- GO:0001889 liver development
- GO:0002040 sprouting angiogenesis
- GO:0002051 osteoblast fate commitment
- GO:0003160 endocardium morphogenesis
- GO:0003700 sequence-specific DNA binding transcription factor activity
- GO:0004872 receptor activity
- GO:0005887 integral to plasma membrane
- GO:0005634 nucleus
- GO:0007368 determination of left/right symmetry
- GO:0007386 compartment pattern formation
- GO:0007409 axonogenesis
- GO:0007440 foregut morphogenesis
- GO:0007492 endoderm development
- GO:0008284 positive regulation of cell proliferation
- GO:0014807 regulation of somitogenesis
- GO:0021915 neural tube development
- GO:0030216 keratinocyte differentiation
- GO:0030324 lung development
- GO:0030514 negative regulation of BMP signaling pathway
- GO:0030900 forebrain development
- GO:0031069 hair follicle morphogenesis
- GO:0031490 chromatin DNA binding
- GO:0032582 negative regulation of gene-specific transcription
- GO:0035116 embryonic hindlimb morphogenesis
- GO:0042640 anagen
- GO:0043065 positive regulation of apoptosis
- GO:0043066 negative regulation of apoptosis
- GO:0043565 sequence-specific DNA binding
- GO:0045618 positive regulation of keratinocyte differentiation
- GO:0045668 negative regulation of osteoblast differentiation
- GO:0046533 negative regulation of photoreceptor cell differentiation
- GO:0048103 somatic stem cell division
- GO:0048663 neuron fate commitment
- GO:0048754 branching morphogenesis of a tube
- GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
- GO:0060740 prostate gland epithelium morphogenesis
- GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development
- Regulatory
- For research purposes only
Applications of Notch 1 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 0.5 | 4.0 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti Notch 1 antibody recognizes a band of approximately 120 kDa in Jurkat and 3T3 lysates
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
|
|
| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
|
|
| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
|
|
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
|
|
| Sheep anti Rabbit IgG:FITC | STAR34B | C F | 1 mg |
|
|
| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
|
|
| Sheep anti Rabbit IgG:DyLight®488 | STAR36D488GA | F IF WB | 0.1 mg | ||
| Sheep anti Rabbit IgG:DyLight®680 | STAR36D680GA | F IF WB | 0.1 mg | ||
| Sheep anti Rabbit IgG:Dylight®800 | STAR36D800GA | F IF WB | 0.1 mg |
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