Notch 1 antibody

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Rabbit anti Notch 1

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
AHP2333 WB 50 µg
Rabbit anti Notch 1 antibody recognizes neurogenic locus notch homolog protein 1 (Notch 1). Notch (DSL) proteins are a family of transmembrane proteins with repeated extracellular EGF domains and the notch (or DSL) domains. These proteins are involved in inhibition in embryogenesis. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells. It is a protein which functions as a receptor for membrane bound ligands and the Notch family members play a role in a variety of developmental processes by controlling cell apoptosis.

Product Details

Target Species
Mouse
Species Cross-Reactivity
Target SpeciesCross Reactivity
Human
Rat Expected from Sequence
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
30% Glycerol
0.5% Bovine Serum Albumin
0.01% Thiomersal
Immunogen
Synthetic peptide corresponding to residues surrounding amino acid 1760 of mouse Notch 1
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml

Storage Information

Storage
Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
12 months from date of despatch

More Information

UniProt
Q01705 Related reagents
Entrez Gene
Notch1 Related reagents
GO Terms
GO:0005515 protein binding
GO:0005509 calcium ion binding
GO:0001701 in utero embryonic development
GO:0001708 cell fate specification
GO:0001837 epithelial to mesenchymal transition
GO:0001889 liver development
GO:0002040 sprouting angiogenesis
GO:0002051 osteoblast fate commitment
GO:0003160 endocardium morphogenesis
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004872 receptor activity
GO:0005887 integral to plasma membrane
GO:0005634 nucleus
GO:0007368 determination of left/right symmetry
GO:0007386 compartment pattern formation
GO:0007409 axonogenesis
GO:0007440 foregut morphogenesis
GO:0007492 endoderm development
GO:0008284 positive regulation of cell proliferation
GO:0014807 regulation of somitogenesis
GO:0021915 neural tube development
GO:0030216 keratinocyte differentiation
GO:0030324 lung development
GO:0030514 negative regulation of BMP signaling pathway
GO:0030900 forebrain development
GO:0031069 hair follicle morphogenesis
GO:0031490 chromatin DNA binding
GO:0032582 negative regulation of gene-specific transcription
GO:0035116 embryonic hindlimb morphogenesis
GO:0042640 anagen
GO:0043065 positive regulation of apoptosis
GO:0043066 negative regulation of apoptosis
GO:0043565 sequence-specific DNA binding
GO:0045618 positive regulation of keratinocyte differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0046533 negative regulation of photoreceptor cell differentiation
GO:0048103 somatic stem cell division
GO:0048663 neuron fate commitment
GO:0048754 branching morphogenesis of a tube
GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0060740 prostate gland epithelium morphogenesis
GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development
Regulatory
For research purposes only

Applications of Notch 1 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 0.5 4.0 ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Western Blotting
Rabbit anti Notch 1 antibody recognizes a band of approximately 120 kDa in Jurkat and 3T3 lysates

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Sheep anti Rabbit IgG:Biotin 2AB02B 1 ml C E P WB
Goat anti Rabbit IgG (Fc):Biotin STAR121B 1 mg E WB
Goat anti Rabbit IgG (Fc):FITC STAR121F 1 mg F
Goat anti Rabbit IgG (Fc):HRP STAR121P 1 mg E WB
Goat anti Rabbit IgG (H/L):HRP STAR124P 1 mg C E WB
Sheep anti Rabbit IgG:FITC STAR34B 1 mg C F
Sheep anti Rabbit IgG:RPE STAR35A 1 ml F
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA 0.1 mg F IF WB
Sheep anti Rabbit IgG:DyLight®549 STAR36D549GA 0.1 mg F IF
Sheep anti Rabbit IgG:DyLight®649 STAR36D649GA 0.1 mg F IF
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA 0.1 mg F IF WB
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA 0.1 mg F IF WB