Rabbit anti histone deacetylase 6 antibody recognizes histone deacetylase 6, also known as HDAC6. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Encoded by HDAC6 gene, histone deacetylase 6 belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains, which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription (provided by RefSeq, Jul 2008).
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
||Expected from Sequence
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 30% Glycerol
0.5% Bovine Serum Albumin
- Synthetic peptide mapping to the N-terminus of mouse HDAC6
- Approx. Protein Concentrations
- IgG concentration 0.2 mg/ml
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
histone deacetylase activity
negative regulation of microtubule depolymerization
zinc ion binding
tubulin deacetylase activity
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
protein complex disassembly
regulation of transcription
cellular response to misfolded protein
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Histone Deacetylase 6 antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti histone deacetylase 6 antibody recognizes a band of approximately 134 kDa in Jurkat cell lysate
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Secondary Antibodies Available