Histone Deacetylase 6 antibody

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Rabbit anti Histone Deacetylase 6

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
AHP2314 P WB 50 µg
Rabbit anti histone deacetylase 6 antibody recognizes histone deacetylase 6, also known as HDAC6. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Encoded by HDAC6 gene, histone deacetylase 6 belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains, which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription (provided by RefSeq, Jul 2008).

Product Details

Target Species
Mouse
Species Cross-Reactivity
Target SpeciesCross Reactivity
Human
Rat Expected from Sequence
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
30% Glycerol
0.5% Bovine Serum Albumin
0.01% Thiomersal
Immunogen
Synthetic peptide mapping to the N-terminus of mouse HDAC6
Approx. Protein Concentrations
IgG concentration 0.2 mg/ml

Storage Information

Storage
Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
12 months from date of despatch

More Information

UniProt
Q9Z2V5 Related reagents
Entrez Gene
Hdac6 Related reagents
GO Terms
GO:0000209 protein polyubiquitination
GO:0003779 actin binding
GO:0004407 histone deacetylase activity
GO:0005829 cytosol
GO:0005634 nucleus
GO:0005881 cytoplasmic microtubule
GO:0006350 transcription
GO:0007026 negative regulation of microtubule depolymerization
GO:0008017 microtubule binding
GO:0008270 zinc ion binding
GO:0016568 chromatin modification
GO:0042903 tubulin deacetylase activity
GO:0043130 ubiquitin binding
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0043241 protein complex disassembly
GO:0045449 regulation of transcription
GO:0048487 beta-tubulin binding
GO:0070842 aggresome assembly
GO:0070846 Hsp90 deacetylation
GO:0071218 cellular response to misfolded protein
GO:0090042 tubulin deacetylation
Regulatory
For research purposes only

Applications of Histone Deacetylase 6 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 20 ug/ml
Western Blotting 0.5 4.0 ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Western Blotting
Rabbit anti histone deacetylase 6 antibody recognizes a band of approximately 134 kDa in Jurkat cell lysate

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Sheep anti Rabbit IgG:Biotin 2AB02B 1 ml C E P WB
Goat anti Rabbit IgG (Fc):Biotin STAR121B 1 mg E WB
Goat anti Rabbit IgG (Fc):FITC STAR121F 1 mg F
Goat anti Rabbit IgG (Fc):HRP STAR121P 1 mg E WB
Goat anti Rabbit IgG (H/L):HRP STAR124P 1 mg C E WB
Sheep anti Rabbit IgG:FITC STAR34B 1 mg C F
Sheep anti Rabbit IgG:RPE STAR35A 1 ml F
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA 0.1 mg F IF WB
Sheep anti Rabbit IgG:DyLight®549 STAR36D549GA 0.1 mg F IF
Sheep anti Rabbit IgG:DyLight®649 STAR36D649GA 0.1 mg F IF
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA 0.1 mg F IF WB
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA 0.1 mg F IF WB