CD289 antibody


CD289 acts as a receptor for unmethylated cytidine-phosphate-guanosine dinucleotides in bacterial DNA (CpG-DNA), playing a primary role in pathogen recognition and activation of innate immunity and has been shown to play a role in defence against systemic mouse cytomegalovirus infection.
Goat anti Mouse CD289 antibody is reported as suitable for use in immunocytochemistry on acetone fixed cells.
Product Details
- Target Species
- Mouse
- Species Cross-Reactivity
-
Target Species Cross Reactivity Human - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to mouse CD289 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
0.1% Bovine Serum Albumin - Immunogen
- Synthetic peptide LSLKYNNLTKVPRQLPPSLEY-C corresponding to amino acids 204-224 within the N-terminal region of mouse CD289.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
Storage Information
- Storage
- Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- Q9NR96
- Q9EQU3
- Entrez Gene
- Tlr9
- TLR9
- GO Terms
- GO:0005886 plasma membrane
- GO:0005515 protein binding
- GO:0002237 response to molecule of bacterial origin
- GO:0005764 lysosome
- GO:0016021 integral to membrane
- GO:0004888 transmembrane receptor activity
- GO:0005768 endosome
- GO:0005789 endoplasmic reticulum membrane
- GO:0006954 inflammatory response
- GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0030277 maintenance of gastrointestinal epithelium
- GO:0032009 early phagosome
- GO:0032715 negative regulation of interleukin-6 production
- GO:0032728 positive regulation of interferon-beta production
- GO:0032733 positive regulation of interleukin-10 production
- GO:0032735 positive regulation of interleukin-12 production
- GO:0032741 positive regulation of interleukin-18 production
- GO:0032755 positive regulation of interleukin-6 production
- GO:0032760 positive regulation of tumor necrosis factor production
- GO:0035197 siRNA binding
- GO:0045078 positive regulation of interferon-gamma biosynthetic process
- GO:0045087 innate immune response
- GO:0045356 positive regulation of interferon-alpha biosynthetic process
- GO:0045359 positive regulation of interferon-beta biosynthetic process
- GO:0050727 regulation of inflammatory response
- GO:0051607 defense response to virus
- GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
- GO:0042742 defense response to bacterium
- GO:0005576 extracellular region
- GO:0005149 interleukin-1 receptor binding
- GO:0007252 I-kappaB phosphorylation
- GO:0008286 insulin receptor signaling pathway
- GO:0008543 fibroblast growth factor receptor signaling pathway
- GO:0010008 endosome membrane
- GO:0016323 basolateral plasma membrane
- GO:0016324 apical plasma membrane
- GO:0032088 negative regulation of NF-kappaB transcription factor activity
- GO:0032717 negative regulation of interleukin-8 production
- GO:0032722 positive regulation of chemokine production
- GO:0032757 positive regulation of interleukin-8 production
- GO:0034122 negative regulation of toll-like receptor signaling pathway
- GO:0034123 positive regulation of toll-like receptor signaling pathway
- GO:0042346 positive regulation of NF-kappaB import into nucleus
- GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
- GO:0043507 positive regulation of JUN kinase activity
- GO:0046330 positive regulation of JNK cascade
- GO:0050729 positive regulation of inflammatory response
- GO:0051092 positive regulation of NF-kappaB transcription factor activity
- Regulatory
- For research purposes only
Applications of CD289 antibody
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Immunohistology - Paraffin | 1:125 | ||
Western Blotting | 1:500 |
- Histology Positive Control Tissue
- Spleen, thymus or tonsil
Secondary Antibodies Available
Description | Product Code | Applications | Pack Size | List Price | Quantity |
---|---|---|---|---|---|
Rabbit anti Goat IgG (Fc):FITC | STAR122F | F | 1 mg |
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Rabbit anti Goat IgG (Fc):HRP | STAR122P | C E WB | 1 mg |
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Useful Reagents Available
Description | Product Code | Applications | Pack Size | List Price | Quantity |
---|---|---|---|---|---|
Antigen Retrieval Buffer, pH8.0 | BUF025A | P | 500 ml | ||
100x Antigen Retrieval Buffer, pH8.0 | BUF025C | P | 50 ml |
Product Specific References
References for CD289 antibody
-
Ripoll, V.M. et al. (2010) Macrophages from BALB/c and CBA/Ca mice differ in their cellular responses to Streptococcus pneumoniae.
J Leukoc Biol. 87: 735-41.
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