CD193 antibody
Goat anti Mouse CD193 antibody recognizes an epitope within the N-terminal (NT) region of mouse CD193, otherwise known as C-C chemokine receptor type 3 or CCR3. CD193 is a 359 amino acid ~42 kDa multi pass transmembrane glycoprotein and member of the G-protein coupled receptor 1 family (UniProt: P51678). CD193 is expressed by basophils, eosinophils, microglia, Th2 cells and dendritic cells.
CD193 acts as a receptor for eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13) and RANTES (CCL5), the former being a chemoattractant for eosinophils and basophils. CD193 is involved in leukocyte chemotaxis and, along with CD191 (CCR1), is implicated as a regulator of T cell and dendritic cell interaction during the process of antigen presentation. CD193 is implicated as an activator of eosinophils in allergic lung disease, and is a useful TH2 cell marker in monitoring immune responses.
Goat anti Mouse CD193 antibody is reported as suitable for use in immunocytochemistry on acetone fixed cells.
CD193 acts as a receptor for eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13) and RANTES (CCL5), the former being a chemoattractant for eosinophils and basophils. CD193 is involved in leukocyte chemotaxis and, along with CD191 (CCR1), is implicated as a regulator of T cell and dendritic cell interaction during the process of antigen presentation. CD193 is implicated as an activator of eosinophils in allergic lung disease, and is a useful TH2 cell marker in monitoring immune responses.
Goat anti Mouse CD193 antibody is reported as suitable for use in immunocytochemistry on acetone fixed cells.
Product Details
- Target Species
- Mouse
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to mouse CD193 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.1% Sodium Azide (NaN3)
0.1% Bovine Serum Albumin - Immunogen
- Synthetic peptide TDEIKTVVESFETTPYEYEWAPPC corresponding to amino acids 5-28 within the N-terminal region of mouse CD193.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
Storage Information
- Storage
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Shelf Life
- 18 months from date of despatch.
More Information
- UniProt
- P51678 Related reagents
- Entrez Gene
- Ccr3 Related reagents
- GO Terms
- GO:0005886 plasma membrane
- GO:0001938 positive regulation of endothelial cell proliferation
- GO:0016021 integral to membrane
- GO:0006935 chemotaxis
- GO:0016493 C-C chemokine receptor activity
- GO:0045766 positive regulation of angiogenesis
- Regulatory
- For research purposes only
Applications of CD193 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin 1 | 1/125 | ||
| Western Blotting | 1/500 |
- 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- Spleen
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Secondary Antibodies Available
| Description | Product Code | Pack Size | Applications | List Price | Quantity |
|---|---|---|---|---|---|
| Rabbit anti Goat IgG (Fc):FITC | STAR122F | 1 mg | F | ||
| Rabbit anti Goat IgG (Fc):HRP | STAR122P | 1 mg | C E WB |
Useful Reagents Available
| Description | Product Code | Pack Size | Applications | List Price | Quantity |
|---|---|---|---|---|---|
| Antigen Retrieval Buffer, pH8.0 | BUF025A | 500 ml | P | ||
| Antigen Retrieval Buffer, pH8.0 | BUF025C | 50 ml | P |
