XIAP antibody

100% Secure


Rabbit anti XIAP

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
AHP2363 WB 50 µg
Rabbit anti XIAP antibody recognizes XIAP (X-linked inhibitor of apoptosis protein) also known as IAP-3 (Inhibitor of apoptosis protein 3) or BIRC (baculoviral IAP repeat-containing protein 4). XIAP is an E3 ubiquitin ligase and acts as an endogenous inhibitor of cell death by suppressing caspases 3, 7, and 9 activities. The protein is also reported to play a role in the activation of the NF-kappa-B cell signaling pathway and the regulation of cyclins and cyclin-dependent kinase inhibitors (CDKIs). In addition to acting as an ubiquitin ligase XIAP has also been reported to have NEDD8 E3 ligase activity.
XIAP has been identified as a potential tumor marker. In addition, aberrant XIAP regulation has been implicated in neurodegenerative and autoimmunity diseases. Mutations in XIAP have been shown to result in lymphoproliferative disorders.

Product Details

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse Expected from Sequence
Rat Expected from Sequence
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
30% Glycerol
0.5% Bovine Serum Albumin
0.01% Thiomersal
Immunogen
Synthetic peptide surrounding amino acid 230 of human XIAP
Approx. Protein Concentrations
IgG concentration 0.2 mg/ml

Storage Information

Storage
Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
12 months from date of despatch

More Information

UniProt
P98170 Related reagents
Entrez Gene
XIAP Related reagents
GO Terms
GO:0005515 protein binding
GO:0006915 apoptosis
GO:0005829 cytosol
GO:0006916 anti-apoptosis
GO:0006974 response to DNA damage stimulus
GO:0008270 zinc ion binding
GO:0008629 induction of apoptosis by intracellular signals
GO:0016874 ligase activity
GO:0043027 caspase inhibitor activity
Regulatory
For research purposes only

Applications of XIAP antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 0.5 4.0 ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Western Blotting
Rabbit anti XIAP recognizes a band of approximately 57 kDa in Jurkat cell lysate

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Sheep anti Rabbit IgG:Biotin 2AB02B 1 ml C E P WB
Goat anti Rabbit IgG (Fc):Biotin STAR121B 1 mg E WB
Goat anti Rabbit IgG (Fc):FITC STAR121F 1 mg F
Goat anti Rabbit IgG (Fc):HRP STAR121P 1 mg E WB
Goat anti Rabbit IgG (H/L):HRP STAR124P 1 mg C E WB
Sheep anti Rabbit IgG:FITC STAR34B 1 mg C F
Sheep anti Rabbit IgG:RPE STAR35A 1 ml F
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA 0.1 mg F IF WB
Sheep anti Rabbit IgG:DyLight®549 STAR36D549GA 0.1 mg F IF
Sheep anti Rabbit IgG:DyLight®649 STAR36D649GA 0.1 mg F IF
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA 0.1 mg F IF WB
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA 0.1 mg F IF WB