Rabbit anti XIAP antibody recognizes XIAP (X-linked inhibitor of apoptosis protein) also known as IAP-3 (Inhibitor of apoptosis protein 3) or BIRC (baculoviral IAP repeat-containing protein 4). XIAP is an E3 ubiquitin ligase and acts as an endogenous inhibitor of cell death by suppressing caspases 3, 7, and 9 activities. The protein is also reported to play a role in the activation of the NF-kappa-B cell signaling pathway and the regulation of cyclins and cyclin-dependent kinase inhibitors (CDKIs). In addition to acting as an ubiquitin ligase XIAP has also been reported to have NEDD8 E3 ligase activity.
XIAP has been identified as a potential tumor marker. In addition, aberrant XIAP regulation has been implicated in neurodegenerative and autoimmunity diseases. Mutations in XIAP have been shown to result in lymphoproliferative disorders.
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
||Expected from Sequence
||Expected from Sequence
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 30% Glycerol
0.5% Bovine Serum Albumin
- Synthetic peptide surrounding amino acid 230 of human XIAP
- Approx. Protein Concentrations
- IgG concentration 0.2 mg/ml
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
response to DNA damage stimulus
zinc ion binding
induction of apoptosis by intracellular signals
caspase inhibitor activity
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of XIAP antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti XIAP recognizes a band of approximately 57 kDa in Jurkat cell lysate
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Secondary Antibodies Available
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