Rabbit anti Human XEDAR antibody detects human X-linked ectodermal dysplasia receptor (XEDAR), a ~33 kDa type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily. XEDAR is a homologue of the ectodermal dysplasia receptor (EDAR), and binds to an isoform of ectodysplasin termed EDA-A2. Binding of ectodysplasin to XEDAR results in the induction of apoptosis, and is thought to be involved ectodermal organ development. XEDAR may also be involved in skeletal muscle development.
Two predominant isoforms of XEDAR exist; XEDAR-s and XEDAR-L, produced by alternative splicing.
- Target Species
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to XEDAR were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- Recombinant human XEDAR.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 18 months from date of despatch.
- Entrez Gene
- GO Terms
tumor necrosis factor receptor activity
integral to plasma membrane
positive regulation of JNK cascade
positive regulation of NF-kappaB transcription factor activity
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of XEDAR antibody
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
- Western Blotting
- AHP1182 detects a band of approximately 33kDa in 293 cell lysates.
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Secondary Antibodies Available
Useful Reagents Available
Product Specific References
Sinha, S.K. et al. (2002) Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor.
J Biol Chem. 277 (47): 44953-61.
Sinha, S.K. & Chaudhary, P.M. (2004) Induction of apoptosis by X-linked ectodermal dysplasia receptor via a caspase 8-dependent mechanism.
J Biol Chem. 279 (40): 41873-81.
Newton, K. et al. (2004) Myodegeneration in EDA-A2 transgenic mice is prevented by XEDAR deficiency.
Mol Cell Biol. 24 (4): 1608-13.