WRN antibody

Rabbit anti WRN

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
WRN

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VPA00006
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Rabbit anti Human WRN antibody recognizes human Werner syndrome ATP-dependent helicase, also known as exonuclease WRN or DNA helicase, RecQ-like type 3. WRN is a 1432 amino acid member of the RecQ helicase subfamily containing single HRDC, helicase C-terminal, helicase ATP-binding and 3'-5' exonuclease domains and is implicated in DNA double-strand break repairs, through interaction with Ku70/80 (Li et al. 2004).

Defects in the WRN gene are responsible for the rare autosomal recessive premature ageing disease known as Werner syndrome, characterized by age-related disorders including atherosclerosis, osteoporosis, non-insulin-dependent diabetes mellitus, ocular cataracts and cancer (Huang et al. 2006).

Rabbit anti Human WRN antibody recognizes human WRN as a single ~200 kDa band in HeLa cell line lysates by western blotting under reducing conditions.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti WRN antibody detects a band of approximately 200 kDa in HeLa cell lysates.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
TRIS-citrate/Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
Synthetic peptide corresponding to an epitope within amino acid residues 1400-1432 of human WRN
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Synonyms
Werner Syndrome Helicase
UniProt
Q14191
Entrez Gene
WRN
GO Terms
GO:0000287 magnesium ion binding
GO:0000403 Y-form DNA binding
GO:0000405 bubble DNA binding
GO:0000723 telomere maintenance
GO:0000731 DNA synthesis involved in DNA repair
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005813 centrosome
GO:0006284 base-excision repair
GO:0006310 DNA recombination
GO:0006979 response to oxidative stress
GO:0008408 3'-5' exonuclease activity
GO:0009378 four-way junction helicase activity
GO:0010225 response to UV-C
GO:0010259 multicellular organismal aging
GO:0042981 regulation of apoptosis
GO:0030145 manganese ion binding
GO:0031297 replication fork processing
GO:0032403 protein complex binding
GO:0042803 protein homodimerization activity
GO:0043140 ATP-dependent 3'-5' DNA helicase activity
GO:0051345 positive regulation of hydrolase activity
GO:0051880 G-quadruplex DNA binding
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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