Wasp antibody

Rabbit anti WASP

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
Wasp

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VPA00348
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Rabbit anti Human WASP antibody recognizes WASP, also known as eczema-thrombocytopenia, thrombocytopenia 1 (X-linked) and wiskott-Aldrich syndrome protein.

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. WAS proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3.

Wiskott-Aldrich syndrome, due to mutatations in the WAS gene, is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia. The WAS gene product (WASP) is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signaling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5′ UTR sequence, has been described (provided by RefSeq, Jul 2008).

Rabbit anti Human WASP antibody detects a band of 60 kDa. Rabbit anti Human WASP antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti WASP detects a band of approximately 60 kDa in Ramos cell lysate.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
KLH-conjugated synthetic peptide corresponding to aa 205-234 of human WASP
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
P42768
Entrez Gene
WAS
GO Terms
GO:0006952 defense response
GO:0007596 blood coagulation
GO:0005829 cytosol
GO:0005083 small GTPase regulator activity
GO:0006955 immune response
GO:0008544 epidermis development
GO:0042802 identical protein binding
GO:0015629 actin cytoskeleton
GO:0050852 T cell receptor signaling pathway
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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