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VAV3 antibody

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Western blot analysis of Jurkat cell lysate and mouse brain, lung and spleen tissue lysates using Rabbit anti VAV3 antibody at a 1/1000 dilution. 3% non-fat dry milk was used for blocking

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Rabbit anti VAV3

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
VAV3

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Technical Suppport
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AHP2720
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Rabbit anti VAV3 antibody recognizes guanine nucleotide exchange factor, also known as VAV-3. It belongs to the VAV family of proteins; the main function of VAV proteins is to work as guanosine nucleotide exchange factors (GEFs) for members of the Rho GTPase family (Bustelo 2014). VAV3 was initially detected in expressed sequence tag (EST) libraries (Movilla and Bustelo 1999). It mediates receptor protein tyrosine kinase signaling (Zeng et al. 2000). Protein overexpression of VAV3 has been reported in several types of human cancer, including breast cancer (Lee et al. 2008) and prostate cancer (Dong et al. 2006).

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to VAV3 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide
50% Glycerol
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 560-680 of human VAV3
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/200 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Western Blotting
Rabbit anti VAV3 antibody detects a band of approximately 105 kDa in Jurkat cell lysate and mouse tissue lysates under reducing conditions

Description Product Code Applications Pack Size List Price Your Price Quantity
TidyBlot Western Blot Detection Reagent:HRP STAR209P WB* 0.5 ml
List Price Your Price
Description TidyBlot Western Blot Detection Reagent:HRP

UniProt
Q9UKW4
Entrez Gene
VAV3
GO Terms
GO:0001525 angiogenesis
GO:0006915 apoptosis
GO:0005829 cytosol
GO:0005070 SH3/SH2 adaptor activity
GO:0005096 GTPase activator activity
GO:0046872 metal ion binding
GO:0006974 response to DNA damage stimulus
GO:0007264 small GTPase mediated signal transduction
GO:0008624 induction of apoptosis by extracellular signals
GO:0042493 response to drug
GO:0030168 platelet activation
GO:0030890 positive regulation of B cell proliferation
GO:0035023 regulation of Rho protein signal transduction
GO:0048011 nerve growth factor receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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