VAV1 (pTyr174) antibody

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WB ResetRabbit anti VAV1 (pTyr174)
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- VAV1 (pTyr174)
Rabbit anti VAV1 (pTyr174) antibody recognizes VAV1, also known as vav guanine nucleotide exchange factor 1 when phosphorylated at tyrosine 174. VAV1 is a member of the Vav family of guanine nucleotide exchange factors (GEFs). GEFs are involved in the activation of small GTPases which play a role in many signaling pathways. Potential substrates for VAV1 activity include Rac1, Cdc42 RhoA and RhoG. VAV1 is phosphorylated on tyrosine 174 leads to conformational changes and activation of VAV1 (Katzav 2015). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Expected from Sequence Rat Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to VAV1 (pTyr174) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
50% Glycerol - Immunogen
- Phospho specific-peptide corresponding to residues surrounding tyrosine 174 of human VAV1
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Western Blotting | ![]() |
1/500 | 1/2000 |
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
Sheep anti Rabbit IgG:FITC | STAR34B | C F | 1 mg |
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Description | Sheep anti Rabbit IgG:FITC | ||||||
Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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Description | Sheep anti Rabbit IgG:RPE |
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
TidyBlot Western Blot Detection Reagent:HRP | STAR209P | WB* | 0.5 ml | Log in | |||
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Description | TidyBlot Western Blot Detection Reagent:HRP |
Further Reading
-
Katzav, S. (2015) Vav1: A Dr. Jekyll and Mr. Hyde protein--good for the hematopoietic system, bad for cancer.
Oncotarget. 6 (30): 28731-42.
- UniProt
- P15498
- Entrez Gene
- VAV1
- GO Terms
- GO:0005886 plasma membrane
- GO:0005515 protein binding
- GO:0003700 sequence-specific DNA binding transcription factor activity
- GO:0006915 apoptosis
- GO:0005829 cytosol
- GO:0005089 Rho guanyl-nucleotide exchange factor activity
- GO:0046872 metal ion binding
- GO:0007264 small GTPase mediated signal transduction
- GO:0008624 induction of apoptosis by extracellular signals
- View More GO Terms
- GO:0030168 platelet activation
- GO:0031295 T cell costimulation
- GO:0035023 regulation of Rho protein signal transduction
- GO:0048011 nerve growth factor receptor signaling pathway
AHP2691


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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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