UBIQUILIN-1 antibody
Rabbit anti UBIQUILIN-1
- Product Type
- PrecisionAb Polyclonal
- Isotype
- Polyclonal IgG
- Format
- Purified
- Specificity
- UBIQUILIN-1
Antibody Quality and Performance Guarantee
| Rabbit anti Human ubiquilin-1 antibody recognizes ubiquilin-1, also known as hPLIC-1 or protein linking IAP with cytoskeleton 1. The UBQLN1 gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease (Mah et al. 2000). Two transcript variants encoding different isoforms have been found for UBQLN1 (provided by RefSeq, Jul 2008). Rabbit anti Human ubiquilin-1 antibody detects a band of 66 kDa. The antibody has been extensively validated for western blotting using whole cell lysates. |
|
- Target Species
- Human
- Western Blotting
- Anti Ubiquilin-1 detects a band of approximately 66 kDa in HEK293 cell lysates.
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid.
- Preparation
- Rabbit polyclonal antibody purified by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline.
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
2% Sucrose. - Immunogen
- Synthetic peptide directed towards the middle region of human ubiquilin-1
- Regulatory
- For research purposes only.
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (H/L):HRP | STAR208P | WB | 2 ml |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
- UniProt
- Q9UMX0
- Entrez Gene
- UBQLN1
- GO Terms
- GO:0000502 proteasome complex
- GO:0001666 response to hypoxia
- GO:0006915 apoptosis
- GO:0005783 endoplasmic reticulum
- GO:0005634 nucleus
- GO:0019900 kinase binding
- GO:0031396 regulation of protein ubiquitination
- GO:0048471 perinuclear region of cytoplasm
VPA00453
160712
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