UBE4B antibody

Rabbit anti UBE4B

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
UBE4B

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VPA00346
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Rabbit anti Human UBE4B antibody recognizes UBE4B, also known as UBOX3, UFD2A-III/UBE4B-III splice isoform, homologous to yeast UFD2, homozygously deleted in neuroblastoma-1, ubiquitin conjugation factor E4B, ubiquitin-fusion degradation protein 2 and ubiquitination factor E4B (homologous to yeast UFD2).

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. The UBE4B gene encodes an additional conjugation factor, E4, which is involved in multi-ubiquitin chain assembly. UBE4B is also the strongest neuroblastoma tumor suppressor gene. Alternatively spliced transcript variants encoding distinct isoforms have been found for UBE4B (provided by RefSeq, Jul 2008).

Rabbit anti Human UBE4B antibody detects a band of 140 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti UBE4B detects a band of approximately 140 kDa in K562 cell lysate.
Product Form
Ig fraction - liquid
Preparation
Rabbit Ig fraction prepared by ammonium sulphate precipitation.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
KLH-conjugated synthetic peptide corresponding to aa 112-142 of human UBE4B
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
O95155
Entrez Gene
UBE4B
GO Terms
GO:0000151 ubiquitin ligase complex
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006915 apoptosis
GO:0005737 cytoplasm
GO:0009411 response to UV
GO:0019899 enzyme binding
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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