Rabbit anti Human TSLP antibody recognizes human TSLP (thymic stromal lymphopoietin), a 132 amino acid secreted haemopoietic cytokine which shares biological properties with interleukin-7 (IL-7), including involvement in B-cell development, and the activation and phosphorylation of STAT3 and STAT5.
TSLP is expressed in the heart, liver and prostate and functions through binding to a receptor complex consisting of the TSLPR (thymic stromal lymphopoietin receptor) and the IL-7R alpha chain. Properties attributed to TSLP include the induction of monocytes to release T cell-attracting chemokines, enhancing the maturation of CD11c+ dendritic cells and their ability to stimulate T cells, and strong evidence suggests that TSLP plays a pivotal role in allergic immune responses.
- Target Species
- Product Form
- Purified IgG - lyophilized
- Reconstitute with 0.1ml distilled water.
For long term storage the addition of 0.09% sodium azide is recommended.
- Antiserum Preparation
- Antisera to human TSLP were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Carrier Free
- Recombinant human TSLP.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Prior to reconstitution store at -20°C.
After reconstitution store at -20°C.
This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 6 months from date of despatch
- Entrez Gene
- GO Terms
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of TSLP antibody
|Immunohistology - Paraffin 1
- 1 This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
Useful Reagents Available
Product Specific References
Liu, Y.J. et al. (2007) TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation.
Annu Rev Immunol. 25: 193-219.
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