TRPA1 antibody

Rabbit anti Human TRPA1

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
TRPA1

Product Code Applications Pack Size List Price Your Price Qty
AHP1331
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Rabbit anti Human TRPA1 antibody detects Transient receptor potential A1 (TRPA1), an excitatory cation channel that is highly expressed in nociceptive neurons and plays an important role in inflammatory pain. TRPA1 mediates the response to the proalgesic bradykinin as well as to pungent irritants found in mustards, garlic, and cinnamon.

TRPA1 may also be involved in hearing (as the mammalian hair cell mechanotransducer) and in the detection of cold stimuli.

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to human TRPA1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.1%Sodium Azide (NaN3)
Immunogen
Synthetic peptide: internal domain of human TRPA1, conjugated to Keyhole Limpet Hemocyanin (KLH).
Approx. Protein Concentrations
IgG concentration 1.0mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1 10 20ug/ml
  1. 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Spinal cord, DRG.

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Further Reading

  1. Story, G.M. & GereauRw4, t.h. (2006) Numbing the senses: role of TRPA1 in mechanical and cold sensation.
    Neuron. 50 (2): 177-80.

RRID
AB_2241112
UniProt
O75762
Entrez Gene
TRPA1
GO Terms
GO:0005887 integral to plasma membrane
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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