Troponin T antibody
Goat anti Human troponin T antibody recognizes troponin T also known as cardiomyopathy, dilated 1D (autosomal dominant), cardiomyopathy, hypertrophic 2 and troponin T cardiac muscle, .
The protein encoded by the TNNT2 gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in TNNT2 have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for TNNT2 undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined (provided by RefSeq, Jul 2008).
Goat anti Human troponin T antibody detects a band of 36 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
The protein encoded by the TNNT2 gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in TNNT2 have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for TNNT2 undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined (provided by RefSeq, Jul 2008).
Goat anti Human troponin T antibody detects a band of 36 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Product Details
- Target Species
- Human
- Western Blotting
- Anti troponin T detects a band of approximately 36 kDa in human heart lysates.
- Product Form
- Purified IgG - liquid
- Preparation
- Goat polyclonal antibody purified by ion exchange chromatography.
- Buffer Solution
- Tris buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide (NaN3)
1% Bovine Serum Albumin - Immunogen
- Peptide with sequence C-RNRINDNQKVSKT, from the C-terminus of the protein
Storage Information
- Storage
- Store undiluted at -20oC, avoiding repeated freeze thaw cycles.
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P45379
- Entrez Gene
- TNNT2
- GO Terms
- GO:0003779 actin binding
- GO:0005829 cytosol
- GO:0005523 tropomyosin binding
- GO:0005861 troponin complex
- GO:0008016 regulation of heart contraction
- GO:0030049 muscle filament sliding
- GO:0030172 troponin C binding
- GO:0031013 troponin I binding
- GO:0032780 negative regulation of ATPase activity
- GO:0032781 positive regulation of ATPase activity
- GO:0051592 response to calcium ion
- GO:0055010 ventricular cardiac muscle tissue morphogenesis
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
- Regulatory
- For research purposes only
Applications of Troponin T antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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