TREX1 antibody
Rabbit anti Human TREX1 antibody recognizes TREX1, also known as 3' repair exonuclease 1, 3'-5' exonuclease TREX1, DNase III and three-prime repair exonuclease 1.
TREX1 encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in TREX1 result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants (provided by RefSeq, Sep 2012).
Rabbit anti Human TREX1 antibody detects a band of 33 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
TREX1 encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in TREX1 result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants (provided by RefSeq, Sep 2012).
Rabbit anti Human TREX1 antibody detects a band of 33 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Product Details
- Target Species
- Human
- Western Blotting
- Anti TREX1 antibody recognizes a band of approximately 33 kDa in Raji cell lysates
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Rabbit polyclonal antibody purified by affinity chromatography on immunogen
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
<50% Glycerol - Immunogen
- Recombinant protein of human TREX1
Storage Information
- Storage
- Store undiluted at -20°C, avoiding repeated freeze thaw cycles
- Guarantee
- As supplied, 12 months from date of despatch
More Information
- UniProt
- Q9NSU2 Related reagents
- Entrez Gene
- TREX1 Related reagents
- GO Terms
- GO:0006260 DNA replication
- GO:0003697 single-stranded DNA binding
- GO:0046872 metal ion binding
- GO:0005635 nuclear envelope
- GO:0006298 mismatch repair
- GO:0006310 DNA recombination
- GO:0008219 cell death
- GO:0008296 3'-5'-exodeoxyribonuclease activity
- GO:0008853 exodeoxyribonuclease III activity
- GO:0032405 MutLalpha complex binding
- GO:0032407 MutSalpha complex binding
- GO:0042803 protein homodimerization activity
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
- Regulatory
- For research purposes only
Applications of TREX1 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Rabbit IgG (H/L):HRP | STAR208P | WB | 2 ml |
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