TREX1 antibody

Rabbit anti TREX1

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
TREX1

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VPA00944
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Rabbit anti Human TREX1 antibody recognizes TREX1, also known as 3' repair exonuclease 1, 3'-5' exonuclease TREX1, DNase III and three-prime repair exonuclease 1.

TREX1 encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in TREX1 result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants (provided by RefSeq, Sep 2012).

Rabbit anti Human TREX1 antibody detects a band of 33 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti TREX1 antibody recognizes a band of approximately 33 kDa in Raji cell lysates
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography on immunogen
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
<50% Glycerol
Immunogen
Recombinant protein of human TREX1
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
Q9NSU2
Entrez Gene
TREX1
GO Terms
GO:0006260 DNA replication
GO:0003697 single-stranded DNA binding
GO:0046872 metal ion binding
GO:0005635 nuclear envelope
GO:0006298 mismatch repair
GO:0006310 DNA recombination
GO:0008219 cell death
GO:0008296 3'-5'-exodeoxyribonuclease activity
GO:0008853 exodeoxyribonuclease III activity
GO:0032405 MutLalpha complex binding
GO:0032407 MutSalpha complex binding
GO:0042803 protein homodimerization activity
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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