TRAF5 antibody

Rabbit anti TRAF5

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
TRAF5

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VPA00804
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Rabbit anti Human TRAF5 antibody recognizes the TRAF5, also known as TNF receptor-associated factor 5 or RING finger protein 84.

The scaffold protein encoded by TRAF5 is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have been characterized (provided by RefSeq, Jul 2008).

Rabbit anti Human TRAF5 antibody detects a band of 64 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti TRAF5 antibody recognizes a band of approximately 64 kDa in HeLa cell lysates.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography on immunogen.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
2% Sucrose
Immunogen
Synthetic peptide directed towards the C terminal region of human TRAF5
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
O00463
Entrez Gene
TRAF5
GO Terms
GO:0005515 protein binding
GO:0006915 apoptosis
GO:0004842 ubiquitin-protein ligase activity
GO:0007165 signal transduction
GO:0005737 cytoplasm
GO:0008270 zinc ion binding
GO:0009898 internal side of plasma membrane
GO:0042981 regulation of apoptosis
GO:0035631 CD40 receptor complex
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0051092 positive regulation of NF-kappaB transcription factor activity
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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