TRAF2 antibody

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Goat anti TRAF2

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified

Product Code	Applications	Pack Size	Your Price	List Price	Quantity
VPA00051 Datasheet	WB SDS	100 µl	Log in		Get Quote

Goat anti Human TRAF2 antibody recognizes human tumor necrosis factor (TNF) receptor associated factor 2 (TRAF2), a member of the TNF receptor associated factor (TRAF) protein family. TRAF2 is an adapter protein and signal transducer, which acts downstream of the TNF receptor. TRAF2 directly binds with TNF receptors and other TRAF proteins, and is essential for TNF alpha mediated activation of MAPK8/JNK and NF-kappaB. TRAF2 plays a role in apoptosis, through the formation of a heterodimeric complex with TRAF1, and interaction with the IAP family members cIAP1 and cIAP2, functioning as a mediator of the anti-apoptotic signals from TNF receptors.

Goat anti Human TRAF2 recognizes TRAF2 as a band of 46 kDa in a range of human cell line lysates. Cross reactivity with rodent cell lines is also observed.

Product Details

Target Species

Human

Western Blotting

Goat anti TRAF2 detects a band of approximately 46 kDa HEK293 cell lysates.

Species Cross-Reactivity

Target Species	Cross Reactivity
Mouse
Rat

N.B. Antibody reactivity and working conditions may vary between species.

Product Form

Purified IgG - liquid

Preparation

Goat polyclonal antibody purified by affinity chromatography

Buffer Solution

TRIS buffered saline

Preservative Stabilisers

0.02% Sodium Azide (NaN₃)
0.5% Bovine Serum Albumin

Immunogen

Synthetic peptide sequence C-KMEAKNSYVRDD from the C-terminal region of TRAF2.

Storage Information

Storage: Store undiluted at -20^oC, avoiding repeated freeze thaw cycles.
Guarantee: 12 months from date of despatch

More Information

UniProt: Q12933
Entrez Gene: TRAF2
GO Terms: GO:0005515 protein binding; GO:0002726 positive regulation of T cell cytokine production; GO:0005829 cytosol; GO:0004842 ubiquitin-protein ligase activity; GO:0004871 signal transducer activity; GO:0005174 CD40 receptor binding; GO:0006919 activation of caspase activity; GO:0007250 activation of NF-kappaB-inducing kinase activity; GO:0008270 zinc ion binding; GO:0008624 induction of apoptosis by extracellular signals; GO:0008633 activation of pro-apoptotic gene products; GO:0009898 internal side of plasma membrane; GO:0032743 positive regulation of interleukin-2 production; GO:0033209 tumor necrosis factor-mediated signaling pathway; GO:0035631 CD40 receptor complex; GO:0043507 positive regulation of JUN kinase activity; GO:0043623 cellular protein complex assembly; GO:0046625 sphingolipid binding; GO:0050870 positive regulation of T cell activation; GO:0051092 positive regulation of NF-kappaB transcription factor activity; GO:0051865 protein autoubiquitination; GO:0070207 protein homotrimerization; GO:0070534 protein K63-linked ubiquitination
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.
Regulatory: For research purposes only

Applications of TRAF2 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting			1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description	Product Code	Applications	Pack Size	Your Price	List Price	Quantity
Donkey anti Sheep/Goat IgG:HRP	STAR88P	C E P WB	1 ml	Log in		Get Quote

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