TR3 Orphan Receptor antibody

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Anti Human TR3 Orphan Receptor Antibody gallery image 1 — Western blot analysis of human thyroid tissue lysate probed with Goat anti TR3 orphan receptor antibody (**AHP2139**), 35μg protein in RIPA buffer. Detection was by chemiluminescence.

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Goat anti Human TR3 Orphan Receptor

Product Type: Polyclonal Antibody
Isotype: Polyclonal IgG
Specificity: TR3 Orphan Receptor

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AHP2139 Datasheet Datasheet SDS SDS	E WB	0.1 mg		Log in	Get Quote
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Goat anti Human TR3 orphan receptor antibody recognizes human TR3 orphan receptor, otherwise known as NUR77, an immediate-early orphan nuclear receptor, and member of the nuclear receptor hormone family, encoded by the NR4A1 gene.

TR3 orphan receptor plays a role in the mediation of macrophage inflammatory responses, and in apoptosis and cell proliferation, through the binding to a variety of response elements. TR3 orphan receptor has been shown to bind to the anti-apoptotic protein Bcl-2, and can be induced by both physiological and physical stress-related stimuli, including tumour necrosis factor (TNF), inflammatory cytokines and magnetic fields.

Goat anti Human TR3 orphan receptor antibody is expected to recognise isoform a of TR3 orphan receptor.

Target Species: Human
Species Cross-Reactivity: Target Species Cross Reactivity

Dog Expected from Sequence

Mouse Expected from Sequence

Rat Expected from Sequence; N.B. Antibody reactivity and working conditions may vary between species.
Product Form: Purified IgG - liquid
Antiserum Preparation: Antiserum to human TR3 orphan receptor was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Buffer Solution: TRIS buffered saline
Preservative Stabilisers: 0.02% Sodium Azide (NaN₃)
0.5% Bovine Serum Albumin
Immunogen: Synthetic peptide sequence C-GRLPSKPKQPPDAS from the internal region of TR3 orphan receptor (NP_002126.2; NP_775180.1).
Approx. Protein Concentrations: IgG concentration 0.5mg/ml
Regulatory: For research purposes only
Guarantee: 12 months from date of despatch

Target Species	Cross Reactivity
Dog	Expected from Sequence
Mouse	Expected from Sequence
Rat	Expected from Sequence

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
ELISA		1/32000
Western Blotting		1.0	3.0ug/ml

Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Western Blotting: AHP2139 detects a band of approximately 60kDa in human thyroid gland cell lysates.

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Synonyms: NUR77/NR4A1
RRID: AB_10717582
UniProt: P22736
Entrez Gene: NR4A1
GO Terms: GO:0003700 sequence-specific DNA binding transcription factor activity; GO:0003707 steroid hormone receptor activity; GO:0005654 nucleoplasm; GO:0008270 zinc ion binding; GO:0048015 phosphatidylinositol-mediated signaling; GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor; GO:0048011 nerve growth factor receptor signaling pathway