TMS1 antibody

Rabbit anti Human TMS1 (C-Terminal)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
TMS1
Region
(C-TERMINAL)

Product Code Applications Pack Size List Price Your Price Qty
AHP1606
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SDS Safety Datasheet SDS
C WB 0.1 mg loader
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Search for Batch Specific Datasheets

Rabbit anti Human TMS1 (C-Terminal) antibody recognizes human TMS1, also known as apoptosis-associated speck-like protein containing a CARD (ASC). It was first identified as a cytosolic soluble protein that forms insoluble aggregates and promotes caspase-mediated apoptosis. The proapoptotic activity is mediated predominantly though the activation of caspase 9. It may also be a component of the inflammasome, where it associates with caspase 1, CARD8 and NALP2 to activate proinflammatory caspases. TMS1 is widely expressed in human tissue.

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to human TMS1 (CT) was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide (NaN3)
Immunogen
A peptide corresponding to aa182-195 of human TMS1.
Approx. Protein Concentrations
IgG concentration 1.0mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Frozen
Western Blotting 1ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Western Blotting
AHP1606 detects a band of approximately 25kDa in HL60 cell lysates.

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Synonyms
ASC
RRID
AB_2185277
UniProt
Q9ULZ3
Entrez Gene
PYCARD
GO Terms
GO:0004197 cysteine-type endopeptidase activity
GO:0006508 proteolysis
GO:0006917 induction of apoptosis
GO:0006919 activation of caspase activity
GO:0008385 IkappaB kinase complex
GO:0008656 caspase activator activity
GO:0032090 Pyrin domain binding
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042803 protein homodimerization activity
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0051092 positive regulation of NF-kappaB transcription factor activity
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

View all Anti-Human Products