TIMP-1 antibody
Rabbit anti TIMP-1
- Product Type
- PrecisionAb Polyclonal
- Isotype
- Polyclonal IgG
- Format
- Purified
- Specificity
- TIMP-1
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| Rabbit anti Human TIMP-1 antibody recognizes TIMP-1, also known as collagenase inhibitor, erythroid potentiating activity, fibroblast collagenase inhibitor or tissue inhibitor of metalloproteinases 1. The TIMP1 gene belongs to the TIMP gene family. The protein encoded by the TIMP1 gene is a natural inhibitor of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of TIMP1 is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that TIMP1 inactivation is polymorphic in human females. TIMP1 is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction (provided by RefSeq, Jul 2008). Rabbit anti Human TIMP1 antibody detects a band of 35 kDa. The antibody has been extensively validated for western blotting using whole cell lysates. |
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- Target Species
- Human
- Western Blotting
- Anti TIMP-1 detects a band of approximately 35 kDa in HeLa cell lysates.
- Product Form
- Purified IgG - liquid.
- Preparation
- Rabbit polyclonal antibody purified by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline.
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
2% Sucrose. - Immunogen
- Synthetic peptide directed towards the N-terminal region of human TIMP-1
- Regulatory
- For research purposes only.
- Guarantee
- 12 months from date of despatch.
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
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| Goat anti Rabbit IgG (H/L):HRP | STAR208P | WB | 2 ml | Log in | |||
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| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
- UniProt
- P01033
- Entrez Gene
- TIMP1
- GO Terms
- GO:0005515 protein binding
- GO:0002576 platelet degranulation
- GO:0046872 metal ion binding
- GO:0005578 proteinaceous extracellular matrix
- GO:0008191 metalloendopeptidase inhibitor activity
- GO:0008284 positive regulation of cell proliferation
- GO:0030168 platelet activation
- GO:0031093 platelet alpha granule lumen
- GO:0043249 erythrocyte maturation
- View More GO Terms
- GO:0051045 negative regulation of membrane protein ectodomain proteolysis
View more products with TIMP-1 specificity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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