TIMP-1 antibody

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Rabbit anti TIMP-1

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Product Code Applications Pack Size List Price Quantity
VPA00502
Datasheet
WB
MSDS
100 µl loader

Rabbit anti Human TIMP-1 antibody recognizes TIMP-1, also known as collagenase inhibitor, erythroid potentiating activity, fibroblast collagenase inhibitor or tissue inhibitor of metalloproteinases 1.

The TIMP1 gene belongs to the TIMP gene family. The protein encoded by the TIMP1 gene is a natural inhibitor of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of TIMP1 is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that TIMP1 inactivation is polymorphic in human females. TIMP1 is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction (provided by RefSeq, Jul 2008).

Rabbit anti Human TIMP1 antibody detects a band of 35 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Product Details

Target Species
Human
Western Blotting
Anti TIMP-1 detects a band of approximately 35 kDa in HeLa cell lysates.
Product Form
Purified IgG - liquid.
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
2% Sucrose.
Immunogen
Synthetic peptide directed towards the N-terminal region of human TIMP-1

Storage Information

Storage
Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
Guarantee
As supplied, 12 months from date of despatch.

More Information

UniProt
P01033 Related reagents
Entrez Gene
TIMP1 Related reagents
GO Terms
GO:0005515 protein binding
GO:0002576 platelet degranulation
GO:0046872 metal ion binding
GO:0005578 proteinaceous extracellular matrix
GO:0008191 metalloendopeptidase inhibitor activity
GO:0008284 positive regulation of cell proliferation
GO:0030168 platelet activation
GO:0031093 platelet alpha granule lumen
GO:0043249 erythrocyte maturation
GO:0051045 negative regulation of membrane protein ectodomain proteolysis
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories
Regulatory
For research purposes only.

Applications of TIMP-1 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (H/L):HRP STAR208P WB 2 ml

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