TGF Alpha antibody

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Sheep anti Human TGF Alpha

Product Type: Polyclonal Antibody
Isotype: Polyclonal IgG

Product Code	Applications	Pack Size	Your Price	List Price	Quantity
9129-7995 Datasheet	E SDS	0.5 mg	Log in		Get Quote

Sheep anti Human TGF alpha antibody recognizes TGF-alpha (transforming growth factor alpha) from human, rat and bovine tissues and fluids. TGF-alpha is a 50 amino acid EGF-related polypeptide expressed in a range of tissues, including skin, pancreas, liver, duodenum, salivary glands, urinary and respiratory systems, and the developing and mature central nervous system (CNS)

TGF-alpha is produced by monocytes, keratinocytes and neuronal cells and stimulates the proliferation of a range of epidermal and epithelial cells, through binding to the epidermal growth factor receptor (EGFR). TGF-alpha is mitogenic for multipotent neural progenitors and is involved in astrogliosis.

This antibody does not react with EGF or TGF-beta.

Product Details

Target Species

Human

Species Cross-Reactivity

Target Species	Cross Reactivity
Rat
Bovine

N.B. Antibody reactivity and working conditions may vary between species.

Product Form

Purified Ig - liquid

Preparation

Purified Ig prepared by ion exchange chromatography

Buffer Solution

Borate buffered saline

Preservative Stabilisers

0.09%

Sodium Azide (NaN₃)

Immunogen

Mature human recombinant TGF-alpha conjugated to KLH.

Approx. Protein Concentrations

IgG concentration 3.1 mg/ml

Storage Information

Storage: This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Guarantee: 12 months from date of despatch

More Information

UniProt: P01135
Entrez Gene: TGFA
GO Terms: GO:0005886 plasma membrane; GO:0000187 activation of MAPK activity; GO:0016021 integral to membrane; GO:0004708 MAP kinase kinase activity; GO:0004871 signal transducer activity; GO:0005154 epidermal growth factor receptor binding; GO:0045741 positive regulation of epidermal growth factor receptor activity; GO:0005615 extracellular space; GO:0008083 growth factor activity; GO:0008283 cell proliferation; GO:0009986 cell surface; GO:0045840 positive regulation of mitosis; GO:0050679 positive regulation of epithelial cell proliferation; GO:0051781 positive regulation of cell division
Regulatory: For research purposes only

Applications of TGF Alpha antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
ELISA

Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.

Secondary Antibodies Available

Description	Product Code	Applications	Pack Size	Your Price	Quantity
Rabbit anti Sheep IgG (H/L):Biotin	5184-2304	C E F WB	1.5 ml	Log in	Get Quote
Donkey anti Sheep/Goat IgG:DyLight®488	STAR88D488GA	F IF	0.1 mg	Log in	Get Quote
Donkey anti Sheep/Goat IgG:HRP	STAR88P	C E P WB	1 ml	Log in	Get Quote

Product Specific References

References for TGF Alpha antibody

Ju, W. et al. (1991) Tumorigenic transformation of NIH 3T3 cells by the autocrine synthesis of transforming growth factor alpha.
New Biol. 3: 380-388.

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