Tfam antibody

Rabbit anti Tfam

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
Tfam

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VPA00464
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Rabbit anti Human TFAM antibody recognizes TFAM, mitochondrial, also known as mitochondrial transcription factor 1, mitochondrial transcription factor A, transcription factor 6, or transcription factor 6-like 2.

The TFAM gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in TFAM are associated with Alzheimer's and Parkinson's diseases (Belin et al. 2007). There are pseudogenes for TFAM on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants (provided by RefSeq, Aug 2012).

Rabbit anti Human TFAM antibody detects a band of 29 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti TFAM detects a band of approximately 29 kDa in Jurkat cell lysates.
Product Form
Purified IgG - liquid.
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
2% Sucrose.
Immunogen
Synthetic peptide directed towards the N terminal region of human TFAM
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
Q00059
Entrez Gene
TFAM
GO Terms
GO:0005515 protein binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005634 nucleus
GO:0006261 DNA-dependent DNA replication
GO:0006356 regulation of transcription from RNA polymerase I promoter
GO:0006391 transcription initiation from mitochondrial promoter
GO:0042645 mitochondrial nucleoid
GO:0045893 positive regulation of transcription, DNA-dependent
GO:0070363 mitochondrial light strand promoter sense binding
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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