TBX1 antibody

Rabbit anti TBX1

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
TBX1

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VPA00634
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WB 100 µl loader
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Rabbit anti Human TBX1 antibody recognizes the T-box transcription factor TBX1, also known as T-box 1 transcription factor C, TGA, CAFS or VCF.

The TBX1 gene is a member of a phylogenetically conserved family of genes sharing a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. TBX1 product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS) and velocardiofacial syndrome (VCFS), common congenital disorders characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where TBX1 has been mapped. Mouse models of DiGeorge syndrome suggest a major role for TBX1 in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for TBX1 (provided by RefSeq, Jul 2008).

Rabbit anti Human TBX1 antibody detects a band of 43 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Rabbit anti TBX1 detects a band of approximately 43 kDa in MCF7 cell lysates.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide
2% Sucrose
Immunogen
Synthetic peptide encompassing part of the middle region of human TBX1
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
O43435
Entrez Gene
TBX1
GO Terms
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003702 RNA polymerase II transcription factor activity
GO:0005634 nucleus
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007507 heart development
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0048538 thymus development
GO:0048703 embryonic viscerocranium morphogenesis
GO:0060017 parathyroid gland development
GO:0060023 soft palate development
GO:0060037 pharyngeal system development
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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