TBX1 antibody
Rabbit anti Human TBX1 antibody recognizes the T-box transcription factor TBX1, also known as T-box 1 transcription factor C, TGA, CAFS or VCF.
The TBX1 gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. TBX1 product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where TBX1 has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for TBX1 in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for TBX1 (provided by RefSeq, Jul 2008).
Rabbit anti Human TBX1 antibody detects a band of 43 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
The TBX1 gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. TBX1 product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where TBX1 has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for TBX1 in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for TBX1 (provided by RefSeq, Jul 2008).
Rabbit anti Human TBX1 antibody detects a band of 43 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Product Details
- Target Species
- Human
- Western Blotting
- Rabbit anti TBX1 detects a band of approximately 43 kDa in MCF7 cell lysates
- Product Form
- Purified IgG - liquid
- Preparation
- Rabbit polyclonal antibody purified by affinity chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
2% Sucrose - Immunogen
- Synthetic peptide encompassing part of the middle region of human TBX1
Storage Information
- Storage
- Store undiluted at -20oC, avoiding repeated freeze thaw cycles.
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- O43435
- Entrez Gene
- TBX1
- GO Terms
- GO:0003700 sequence-specific DNA binding transcription factor activity
- GO:0003702 RNA polymerase II transcription factor activity
- GO:0005634 nucleus
- GO:0006357 regulation of transcription from RNA polymerase II promoter
- GO:0007507 heart development
- GO:0042803 protein homodimerization activity
- GO:0043565 sequence-specific DNA binding
- GO:0048538 thymus development
- GO:0048703 embryonic viscerocranium morphogenesis
- GO:0060017 parathyroid gland development
- GO:0060023 soft palate development
- GO:0060037 pharyngeal system development
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
- Regulatory
- For research purposes only
Applications of TBX1 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Rabbit IgG (H/L):HRP | STAR208P | WB | 2 ml |
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