Rabbit anti TBL1X antibody recognizes Transducin Beta Like 1 X-Linked (TBL1X), also known as SMAP55 and F-box-like/WD repeat-containing protein TBL1X.
TBL1X is linked to the X chromosome, while TBL1Y is encoded by the same gene on the Y chromosome, and both are closely related to the co-repressor of nuclear hormone transcription factors TBLR1 (Zhang et al. 2006). Similarly, TBL1X is an F-box-like protein that plays an essential role in the silencing mediator for retinoid and thyroid hormone receptors complex (Heinen et al. 2016). TBLR1 functions as an oncogene and is upregulated in colorectal cancer, and TBLR1 knockdown has been shown to inhibit invasive growth of head and neck squamous cell carcinoma cells (Li and Wang. 2008).
- Target Species
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to TBL1X was raised by repeated immunization of rabbits with highly purified antigen
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
- A synthetic peptide corresponding to a sequence within amino acids 100-200 of human TBL1X (NP_005638.1)
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
transcription corepressor activity
sensory perception of sound
protein C-terminus binding
transcription factor binding
negative regulation of gene-specific transcription from RNA polymerase II promoter
transcription activator activity
transcriptional repressor complex
protein domain specific binding
proteasomal ubiquitin-dependent protein catabolic process
cellular lipid metabolic process
positive regulation of transcription from RNA polymerase II promoter
canonical Wnt receptor signaling pathway
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of TBL1X antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available