TBL1X antibody

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Rabbit anti TBL1X

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Product Code Applications Pack Size List Price Quantity
AHP2998
Datasheet
WB
SDS
50 µl loader

Rabbit anti TBL1X antibody recognizes Transducin Beta Like 1 X-Linked (TBL1X), also known as SMAP55 and F-box-like/WD repeat-containing protein TBL1X.

TBL1X is linked to the X chromosome, while TBL1Y is encoded by the same gene on the Y chromosome, and both are closely related to the co-repressor of nuclear hormone transcription factors TBLR1 (Zhang et al. 2006). Similarly, TBL1X is an F-box-like protein that plays an essential role in the silencing mediator for retinoid and thyroid hormone receptors complex (Heinen et al. 2016). TBLR1 functions as an oncogene and is upregulated in colorectal cancer, and TBLR1 knockdown has been shown to inhibit invasive growth of head and neck squamous cell carcinoma cells (Li and Wang. 2008).

Product Details

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to TBL1X was raised by repeated immunization of rabbits with highly purified antigen
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide
50% Glycerol
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human TBL1X (NP_005638.1)

Storage Information

Storage
Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Guarantee
12 months from date of despatch

More Information

UniProt
O60907
Entrez Gene
TBL1X
GO Terms
GO:0003714 transcription corepressor activity
GO:0042393 histone binding
GO:0005876 spindle microtubule
GO:0007605 sensory perception of sound
GO:0008013 beta-catenin binding
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
GO:0010843 promoter binding
GO:0016563 transcription activator activity
GO:0017053 transcriptional repressor complex
GO:0019904 protein domain specific binding
GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
GO:0044255 cellular lipid metabolic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060070 canonical Wnt receptor signaling pathway
Regulatory
For research purposes only

Applications of TBL1X antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/500 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (Fc):Biotin STAR121B E WB 1 mg loader
Goat anti Rabbit IgG (Fc):FITC STAR121F F 1 mg loader
Goat anti Rabbit IgG (Fc):HRP STAR121P E WB 1 mg loader
Goat anti Rabbit IgG (H/L):HRP STAR124P C E WB 1 mg loader
Sheep anti Rabbit IgG:FITC STAR34B C F 1 mg loader
Sheep anti Rabbit IgG:RPE STAR35A F 1 ml loader
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA F IF WB 0.1 mg