TBL1X antibody

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Anti TBL1X Antibody gallery image 1 — Western blot analysis was performed by loading 25µg of various whole cell lysates probed with Rabbit anti TBL1X (**AHP2998**) at 1/1000 dilution. Arrow points to TBL1X (molecular weight 60 kDa).

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Rabbit anti TBL1X

Product Type: Polyclonal Antibody
Isotype: Polyclonal IgG
Specificity: TBL1X

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AHP2998 Datasheet Datasheet SDS SDS	WB	50 µl		Log in	Get Quote
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Rabbit anti TBL1X antibody recognizes Transducin Beta Like 1 X-Linked (TBL1X), also known as SMAP55 and F-box-like/WD repeat-containing protein TBL1X.

TBL1X is linked to the X chromosome, while TBL1Y is encoded by the same gene on the Y chromosome, and both are closely related to the co-repressor of nuclear hormone transcription factors TBLR1 (Zhang et al. 2006). Similarly, TBL1X is an F-box-like protein that plays an essential role in the silencing mediator for retinoid and thyroid hormone receptors complex (Heinen et al. 2016). TBLR1 functions as an oncogene and is upregulated in colorectal cancer, and TBLR1 knockdown has been shown to inhibit invasive growth of head and neck squamous cell carcinoma cells (Li and Wang. 2008).

Target Species: Human
Product Form: Purified IgG - liquid
Antiserum Preparation: Antiserum to TBL1X was raised by repeated immunization of rabbits with highly purified antigen
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: 0.02% Sodium Azide
50% Glycerol
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human TBL1X (NP_005638.1)
Regulatory: For research purposes only
Guarantee: 12 months from date of despatch

Store at -20^oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/500	1/2000

Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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UniProt: O60907
Entrez Gene: TBL1X
GO Terms: GO:0003714 transcription corepressor activity; GO:0042393 histone binding; GO:0005876 spindle microtubule; GO:0007605 sensory perception of sound; GO:0008013 beta-catenin binding; GO:0008022 protein C-terminus binding; GO:0008134 transcription factor binding; GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter; GO:0010843 promoter binding; View More GO Terms; GO:0016563 transcription activator activity; GO:0017053 transcriptional repressor complex; GO:0019904 protein domain specific binding; GO:0043161 proteasomal ubiquitin-dependent protein catabolic process; GO:0044255 cellular lipid metabolic process; GO:0045944 positive regulation of transcription from RNA polymerase II promoter; GO:0060070 canonical Wnt receptor signaling pathway