TAGLN antibody

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Anti TAGLN Antibody (PrecisionAb Polyclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with TAGLN antibody followed by detection with HRP conjugated Donkey anti Sheep/Goat IgG (1/10,000, STAR88P) and visualized on the ChemiDoc MP with 2 second exposure. Arrow points to TAGLN (molecular weight 22 kDa)

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Goat anti TAGLN

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified
Specificity: TAGLN

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Goat anti Human TAGLN antibody recognizes human TAGLN (transgelin), otherwise known as SM22-alpha. TAGLN is a shape change sensitive, actin cross-linking/gelling protein, and a member of the calponin family. TAGLN plays a role in calcium interactions and contractile properties of the cell.

TAGLN is ubiquitously expressed by vascular and visceral smooth muscle, is an early marker of smooth muscle differentiation and is overexpressed by senescent human fibroblasts. TAGLN is a tumor suppressor protein (Assinder et al. 2009), with markedly reduced expression in colorectal cancer samples, and may serve as an important biomarker of malignancy.

Goat anti Human TAGLN antibody recognizes TAGLN as a band of 22 kDa in a wide range of human cell line lysates. Cross reactivity with rodent cell lines is also observed.

Target Species: Human
Western Blotting: Goat anti TAGLN detects a band of approximately 22 kDa in HeLa cell lysates.
Species Cross-Reactivity: Target Species Cross Reactivity

Mouse

Rat; N.B. Antibody reactivity and working conditions may vary between species.
Product Form: Purified IgG - liquid
Preparation: Goat polyclonal antibody purified by affinity chromatography.
Buffer Solution: TRIS buffered saline.
Preservative Stabilisers: 0.02% Sodium Azide (NaN₃)
0.5% Bovine Serum Albumin
Immunogen: Synthetic peptide sequence C-MTGYGRPRQIIS from the C-terminal region of TAGLN.
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Target Species	Cross Reactivity
Mouse
Rat

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting			1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.