STIM1 antibody

Rabbit anti STIM1

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
STIM1

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VPA00188
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Rabbit anti Human STIM1 antibody recognizes the stromal interaction molecule 1 (STIM1).

STIM1 is a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. STIM1 may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in STIM1 are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. STIM1 is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of STIM1 situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of STIM1 results in multiple transcript variants (provided by RefSeq, May 2013).

Rabbit anti Human STIM1 antibody detects a band of 85 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti STIM1 detects a band of approximately 85 kDa in Jurkat cell lysates.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
<30% Glycerol
Immunogen
Synthetic peptide corresponding to an area near the C terminus of human STIM1
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
Q13586
Entrez Gene
STIM1
GO Terms
GO:0005509 calcium ion binding
GO:0005887 integral to plasma membrane
GO:0005513 detection of calcium ion
GO:0005874 microtubule
GO:0006816 calcium ion transport
GO:0030168 platelet activation
GO:0030176 integral to endoplasmic reticulum membrane
GO:0032237 activation of store-operated calcium channel activity
GO:0051010 microtubule plus-end binding
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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