STAT6 (pTyr641) antibody

Rabbit anti STAT6 (pTyr641)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
STAT6 (pTyr641)

Product Code Applications Pack Size List Price Your Price Qty
AHP2690
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SDS Safety Datasheet SDS
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Rabbit anti STAT6 (pTyr641) antibody recognizes STAT6, also known as IL-4 Stat when phosphorylated at tyrosine 641. STAT6 is a member of the STAT family of transcription factors. STATs reside in the cytosol until activated. Upon activation STATs dimerize and translocate to the nucleus where they exert their transcriptional effects. STAT6 is phosphorylated at tyrosine 641 by Janus associated kinases (JAKs) leading to dimerization and relocation to the nucleus (Wurster et al. 2000).

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to STAT6 (pTyr641) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide
50% Glycerol
Immunogen
Phospho specific-peptide corresponding to residues surrounding tyrosine 641 of human STAT6
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/50 1/100
Western Blotting 1/500 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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Further Reading

  1. Wurster, A.L. et al. (2000) The biology of Stat4 and Stat6.
    Oncogene. 19 (21): 2577-84.

UniProt
P42226
Entrez Gene
STAT6
GO Terms
GO:0005515 protein binding
GO:0005509 calcium ion binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005829 cytosol
GO:0004871 signal transducer activity
GO:0005634 nucleus
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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