Rabbit anti STAT5A (pTyr694) antibody
recognizes STAT5A, also known as signal transducer and activator of transcription 5A when phosphorylated at tyrosine 694. STAT5A is a member of the STAT family of transcription factors. Members of the STAT family reside in the cytosol until activated. Upon activation, STATs dimerize and translocate to the nucleus where they exert their transcriptional effects. STAT5a is phosphorylated at tyrosine 694 by members of JAK family of kinases as well as receptor tyrosine kinases (Coffer et al. 2000
). Phosphorylation at tyrosine 694 is crucial for activation of STAT5a.
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
||Expected from Sequence
||Expected from Sequence
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to STAT5A (pTyr694) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
- Phospho specific-peptide corresponding to residues surrounding tyrosine 694 of human STAT5A
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
allantoin metabolic process
calcium ion binding
sequence-specific DNA binding transcription factor activity
citrate metabolic process
2-oxoglutarate metabolic process
succinate metabolic process
oxaloacetate metabolic process
isoleucine metabolic process
valine metabolic process
creatine metabolic process
fatty acid metabolic process
taurine metabolic process
creatinine metabolic process
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of STAT5A (pTyr694) antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Copyright © 2021 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
Useful Reagents Available
Product Specific References
Coffer, P.J. et al. (2000) The role of STATs in myeloid differentiation and leukemia.
Oncogene. 19 (21): 2511-22.
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