Rabbit anti STAT5B antibody recognizes signal transducer and activator of transcription 5B (STAT5B), a member of the STAT protein family, which plays an important role in cell growth, survival differentiation and transformation, transducing signals from cytokine receptors to the nucleus. STAT5B is tyrosine phosphorylated by members of the Janus kinase family in response to cytokines and growth factor stimulation. Phosphorylation results in STAT activation and the formation of STAT5 homo- and STAT5/STAT3 heterodimers. STAT dimers translocate from the cytoplasm to the nucleus where they act as transcription factors. Deregulated JAK/STAT signaling has been implicated in a variety of cancers; STATs can regulate the tumor microenvironment and trigger a shift from cancer inhibition to promotion.
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Synthetic peptide surrounding amino acid 777 of human STAT5
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
allantoin metabolic process
calcium ion binding
sequence-specific DNA binding transcription factor activity
citrate metabolic process
2-oxoglutarate metabolic process
succinate metabolic process
oxaloacetate metabolic process
isoleucine metabolic process
valine metabolic process
creatine metabolic process
fatty acid metabolic process
taurine metabolic process
response to estradiol stimulus
glucocorticoid receptor binding
creatinine metabolic process
JAK-STAT cascade involved in growth hormone signaling pathway
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of STAT5 antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti STAT5 antibody recognizes a band of approximately 95 kDa in 3T3 cell lysate and rat kidney tissue lysate
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Secondary Antibodies Available