Rabbit anti STAT2 (pTyr690) antibody recognizes STAT2, also known as p113 when phosphorylated at tyrosine 690. STAT2 is a member of the STAT family of transcription factors. Upon ligand binding receptor associated kinases phosphorylate STATs causing them to dimerize and translocate to the nucleus. STAT2 forms a heterodimer with STAT1 where promotes transcription at interferon-sensitive response elements. Phosphorylation of STAT2 at tyrosine 690 by JAKs promotes the dimerization with STAT1.
- Target Species
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to STAT2 (pTyr690) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
- Phospho specific-peptide corresponding to residues surrounding tyrosine 690 of human STAT2
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
calcium ion binding
sequence-specific DNA binding transcription factor activity
response to virus
signal transducer activity
regulation of transcription from RNA polymerase II promoter
interspecies interaction between organisms
type I interferon-mediated signaling pathway
regulation of type I interferon-mediated signaling pathway
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of STAT2 (pTyr690) antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
Useful Reagents Available