SRF antibody

Rabbit anti SRF

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
SRF

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VPA00830
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Rabbit anti Human SRF antibody recognizes the serum response factor (SRF).

SRF encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. SRF is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs) (provided by RefSeq, Jul 2008).

Rabbit anti Human SRF antibody detects a band of 67 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti SRF antibody recognizes a band of approximately 67 kDa in Jurkat cell lysates
Species Cross-Reactivity
Target SpeciesCross Reactivity
African green monkey
Alpaca
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography on immunogen
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
2% Sucrose
Immunogen
Synthetic peptide corresponding to a portion of SRF
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
P11831
Entrez Gene
SRF
GO Terms
GO:0001829 trophectodermal cell differentiation
GO:0001947 heart looping
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003704 specific RNA polymerase II transcription factor activity
GO:0005783 endoplasmic reticulum
GO:0005634 nucleus
GO:0008134 transcription factor binding
GO:0045987 positive regulation of smooth muscle contraction
GO:0009636 response to toxin
GO:0009725 response to hormone stimulus
GO:0010735 positive regulation of transcription via serum response element binding
GO:0010736 serum response element binding
GO:0034097 response to cytokine stimulus
GO:0042803 protein homodimerization activity
GO:0045597 positive regulation of cell differentiation
GO:0046716 muscle cell homeostasis
GO:0048666 neuron development
GO:0051150 regulation of smooth muscle cell differentiation
GO:0060055 angiogenesis involved in wound healing
GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter
GO:0090398 cellular senescence
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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