SOX2 antibody

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Anti SOX2 Antibody (PrecisionAb Polyclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with SOX2 antibody followed by detection with Goat anti Rabbit HRP conjugated(1/10,000,STAR208P) and visualized on the ChemiDoc MP with 43 second exposure. Arrow points to SOX2 (molecular weight 35 kDa)

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Rabbit anti SOX2

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified
Specificity: SOX2

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VPA00238 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Rabbit anti Human SOX2 antibody recognizes the transcription factor SOX2, also known as SRY-related HMG-box gene 2.

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. SOX2 is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in the SOX2 gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. SOX2 lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT) (provided by RefSeq, Jul 2008).

Rabbit anti Human SOX2 antibody detects a band of 35 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti SOX2 detects a band of approximately 35 kDa in NTERA-2 cell lysates.
Product Form: Purified IgG - liquid
Preparation: Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃).
Immunogen: KLH conjugated synthetic peptide between 282-316 amino acids from the C-terminal region of human SOX2
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Rabbit IgG (H/L):HRP	STAR208P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Rabbit IgG (H/L):HRP

UniProt: P48431
Entrez Gene: SOX2
GO Terms: GO:0005515 protein binding; GO:0001649 osteoblast differentiation; GO:0003700 sequence-specific DNA binding transcription factor activity; GO:0005829 cytosol; GO:0005667 transcription factor complex; GO:0006325 chromatin organization; GO:0007050 cell cycle arrest; GO:0009611 response to wounding; GO:0010843 promoter binding; View More GO Terms; GO:0021781 glial cell fate commitment; GO:0035019 somatic stem cell maintenance; GO:0035198 miRNA binding; GO:0043281 regulation of caspase activity; GO:0043410 positive regulation of MAPKKK cascade; GO:0045944 positive regulation of transcription from RNA polymerase II promoter; GO:0050680 negative regulation of epithelial cell proliferation; GO:0070848 response to growth factor stimulus; GO:0090090 negative regulation of canonical Wnt receptor signaling pathway