SMAD6 antibody

Rabbit anti SMAD6

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
SMAD6

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VPA00295
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Rabbit anti Human SMAD6 antibody recognizes SMAD6, also known as MAD homolog 6, SMAD and mothers against decapentaplegic homolog 6.

The protein encoded by the SMAD6 gene belongs to the SMAD family of proteins, which are related to Drosophila “mothers against decapentaplegic” (Mad) and C. elegans “Sma”. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for SMAD6 (provided by RefSeq, May 2009).

Rabbit anti SMAD6 antibody detects a band of 62 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti SMAD6 detects a band of approximately 62 kDa in Jurkat cell lysate.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
KLH-conjugated synthetic peptide corresponding to aa 358-386 of human SMAD6
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
O43541
Entrez Gene
SMAD6
GO Terms
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005829 cytosol
GO:0030617 transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
GO:0005667 transcription factor complex
GO:0006355 regulation of transcription, DNA-dependent
GO:0006955 immune response
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007352 zygotic specification of dorsal/ventral axis
GO:0010991 negative regulation of SMAD protein complex assembly
GO:0030509 BMP signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0031625 ubiquitin protein ligase binding
GO:0034616 response to laminar fluid shear stress
GO:0034713 type I transforming growth factor beta receptor binding
GO:0043066 negative regulation of apoptosis
GO:0043154 negative regulation of caspase activity
GO:0045750 positive regulation of S phase of mitotic cell cycle
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0070410 co-SMAD binding
GO:0070411 I-SMAD binding
GO:0070412 R-SMAD binding
GO:0070698 type I activin receptor binding
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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