SEC61B antibody

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Anti SEC61B Antibody gallery image 1 — Western blot analysis of various cell and tissue lysates using Rabbit anti SEC61B antibody at a 1/1000 dilution. 3% non-fat dry milk was used for blocking

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Rabbit anti SEC61B

Product Type: Polyclonal Antibody
Isotype: Polyclonal IgG
Specificity: SEC61B

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AHP2721 Datasheet Datasheet SDS SDS	WB	50 µl		Log in	Get Quote
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Rabbit anti SEC61B antibody recognizes protein transport protein Sec61 subunit beta (SEC61B). SEC61B is a subunit of the SEC61 protein translocation channel at the endoplasmic reticulum (Pfeffer et al. 2015). The SEC61 translocon is important for protein import and export (Rapoport 2007). SEC61B is important in EGF R trafficking to the nucleus (Liao and Carpenter 2007). Measurement of SEC61B autoantibody levels may provide an alternative detection indicator for human colorectal cancer (Fan et al. 2011).

Target Species: Human
Species Cross-Reactivity: Target Species Cross Reactivity

Mouse; N.B. Antibody reactivity and working conditions may vary between species.
Product Form: Purified IgG - liquid
Antiserum Preparation: Antiserum to SEC61B was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: 0.02% Sodium Azide
50% Glycerol
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-96 of human SEC61B
Regulatory: For research purposes only
Guarantee: 12 months from date of despatch

Target Species	Cross Reactivity
Mouse

Store at -20^oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/500	1/2000

Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Western Blotting: Rabbit anti SEC61B antibody detects a band of approximately 12 kDa in various cell and tissue lysates under reducing conditions

Description	Product Code	Applications	Pack Size	Your Price
TidyBlot Western Blot Detection Reagent:HRP	STAR209P	WB*	0.5 ml	Log in	Get Quote
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Description	TidyBlot Western Blot Detection Reagent:HRP

UniProt: P60468
Entrez Gene: SEC61B
GO Terms: GO:0000060 protein import into nucleus, translocation; GO:0016021 integral to membrane; GO:0030433 ER-associated protein catabolic process; GO:0030970 retrograde protein transport, ER to cytosol; GO:0031205 endoplasmic reticulum Sec complex; GO:0048408 epidermal growth factor binding; GO:0055085 transmembrane transport