RAP1A/RAP1B encodes members of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. The RAP1A protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. The RAP1B protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. RAP1B also plays a role in regulating outside-in signaling in platelets. Alternate splicing of RAP1A and RAP1B have been known to produce multiple transcript variants. Pseudogenes of RAP1A have been defined on chromosomes 14 and 17 (provided by RefSeq, May 2014). Pseudogenes of RAP1B are found on chromosomes 3, 5, 6 and 9. (provided by RefSeq, Oct 2011).
Rabbit anti Human RAP1A/ RAP1B antibody detects a band of 26 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
- Target Species
- Western Blotting
- Anti RAP1A/B detects a band of approximately 26 kDa in HEK293 cell lysates.
- Species Cross-Reactivity
Target Species Cross Reactivity Mouse
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid.
- Rabbit polyclonal antibody purified by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline.
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Synthetic peptide directed towards the N terminal region of human RAP1B
- Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
- GO:0005886 plasma membrane
- GO:0005515 protein binding
- GO:0003924 GTPase activity
- GO:0007596 blood coagulation
- GO:0005829 cytosol
- GO:0005525 GTP binding
- GO:0006112 energy reserve metabolic process
- GO:0050796 regulation of insulin secretion
- GO:0019003 GDP binding
- PrecisionAb is a trademark of Bio-Rad Laboratories
- For research purposes only.
Applications of RAP1A/B antibody
|Application Name||Verified||Min Dilution||Max Dilution|
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
Secondary Antibodies Available
|Description||Product Code||Applications||Pack Size||List Price||Quantity|
|Goat anti Rabbit IgG (H/L):HRP||STAR208P||WB||2 ml|