RAGE antibody

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Rabbit anti RAGE

Rabbit anti-human RAGE antibody recognizes advanced glycosylation end product-specific receptor, also known as RAGE isoform NtRAGE-delta, RAGE isoform sRAGE-delta or receptor for advanced glycation end-products variant 20.

Product Type
PrecisionAb™ Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
VPA00582 WB 100 µl
Rabbit anti Human RAGE antibody recognizes RAGE also known as advanced glycosylation end product-specific receptor, RAGE isoform NtRAGE-delta, AGER or receptor for advanced glycation end-products variant 20.

The advanced glycosylation end product (AGE) receptor encoded by the AGER gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for AGER (Hudson et al. 2008) (provided by RefSeq, May 2011).

Rabbit anti Human RAGE antibody detects a band of 55 kDa. The antibody has been extensively validated for western blotting using tissue and whole cell lysates.

Product Details

Target Species
Human
Western Blotting
Anti RAGE detects a band of approximately 55 kDa in mouse lung tissue
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
2% Sucrose
Immunogen
Synthetic peptide directed towards the N terminal region of human RAGE
Instructions For Use
Please refer to the PrecisionAb western blotting protocol. For additional information on secondary antibody dilution and exposure time see product web page.

Storage Information

Storage
Store undiluted at -20oC, avoiding repeated freeze thaw cycles
Shelf Life
As supplied, 12 months from date of despatch

More Information

UniProt
Q15109 Related reagents
Entrez Gene
AGER Related reagents
GO Terms
GO:0004888 transmembrane receptor activity
GO:0005887 integral to plasma membrane
GO:0006954 inflammatory response
GO:0007166 cell surface receptor linked signaling pathway
GO:0031175 neuron projection development
GO:0045087 innate immune response
GO:0048155 S100 alpha binding
GO:0051092 positive regulation of NF-kappaB transcription factor activity
Acknowledgements
PrecisionAbâ„¢ is a trademark of Bio-Rad Laboratories
Regulatory
For research purposes only

Applications of RAGE antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

PrecisionAb antibodies have been extensively validated for the western blot application. The antibody has been validated at the suggested dilution. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependant on sample type.

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Goat anti Rabbit IgG (H/L):HRP STAR208P 2 ml WB

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