RAGE antibody

Rabbit anti RAGE

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
RAGE

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VPA00582
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Rabbit anti Human RAGE antibody recognizes RAGE also known as advanced glycosylation end product-specific receptor, RAGE isoform NtRAGE-delta, AGER or receptor for advanced glycation end-products variant 20.

The advanced glycosylation end product (AGE) receptor encoded by the AGER gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for AGER (Hudson et al. 2008) (provided by RefSeq, May 2011).

Rabbit anti Human RAGE antibody detects a band of 55 kDa. The antibody has been extensively validated for western blotting using tissue and whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti RAGE detects a band of approximately 55 kDa in mouse lung tissue.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid.
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
2% Sucrose.
Immunogen
Synthetic peptide directed towards the N terminal region of human RAGE
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
Q15109
Entrez Gene
AGER
GO Terms
GO:0004888 transmembrane receptor activity
GO:0005887 integral to plasma membrane
GO:0006954 inflammatory response
GO:0007166 cell surface receptor linked signaling pathway
GO:0031175 neuron projection development
GO:0045087 innate immune response
GO:0048155 S100 alpha binding
GO:0051092 positive regulation of NF-kappaB transcription factor activity
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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