Rabbit anti PTPN6 antibody recognizes tyrosine-protein phosphatase non-receptor type 6 (PTPN6) also known as hematopoietic cell protein tyrosine phosphatase. PTPN6 belongs to the protein tyrosine phosphatase family and interacts with surface receptors such as CD117 and epidermal growth factor receptor (EGFR) which have undergone tyrosine phosphorylation.
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
||Expected from Sequence
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to PTPN6 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
- Recombinant human PTPN6
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
protein tyrosine phosphatase activity
G-protein coupled receptor protein signaling pathway
positive regulation of cell proliferation
positive regulation of phosphatidylinositol 3-kinase cascade
T cell costimulation
cell junction assembly
negative regulation of peptidyl-tyrosine phosphorylation
interferon-gamma-mediated signaling pathway
regulation of interferon-gamma-mediated signaling pathway
type I interferon-mediated signaling pathway
regulation of type I interferon-mediated signaling pathway
regulation of G1/S transition of mitotic cell cycle
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of PTPN6 antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti PTPN6 antibody detects a band of approximately 65 kDa in cell lysates and tissue lysates under reducing conditions
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Secondary Antibodies Available
Useful Reagents Available