PTK2B (pTyr402) antibody
Rabbit anti PTK2B (pTyr402)
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- PTK2B (pTyr402)
Antibody Quality and Performance Guarantee
| Rabbit anti PTK2B (pTyr402) antibody recognizes protein-tyrosine kinase 2-beta, also known as CADTK, CAKB, FADK 2, PYK2, when phosphorylated at tyrosine 402. It is a non-receptor tyrosine kinase that regulates cell migration and mediates transfer of signals from the cell surface to the cytoskeleton (Duong et al. 2001, Avraham et al. 2000). Lysophosphatidic acid (LPA) and bradykinin induce tyrosine phosphorylation of PTK2B (Dikic et al. 1996). Phosphorylation of PTK2B on tyrosine 402 is important for binding with SH2 domain of SRC (Dikic et al. 1996). In Jurkat T cells, tyrosine 402 is involved in interleukin-2 production (Katagiri et al. 2000). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to PTK2B (pTyr402) was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
50% Glycerol - Immunogen
- A phospho specific peptide corresponding to residues surrounding tyrosine 402 of human PTK2B
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/500 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti PTK2B (pTyr402) antibody detects a band of approximately 116 kDa in HEK293 cell lysate under reducing conditions
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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| Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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| Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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| Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
| Sheep anti Rabbit IgG:FITC | STAR34B | C F | 1 mg |
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| Description | Sheep anti Rabbit IgG:FITC | ||||||
| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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| List Price | Your Price | ||||||
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| Description | Sheep anti Rabbit IgG:RPE | ||||||
- UniProt
- Q14289
- Entrez Gene
- PTK2B
- GO Terms
- GO:0006915 apoptosis
- GO:0005829 cytosol
- GO:0004715 non-membrane spanning protein tyrosine kinase activity
- GO:0004871 signal transducer activity
- GO:0005524 ATP binding
- GO:0007172 signal complex assembly
- GO:0008284 positive regulation of cell proliferation
AHP2743
148753
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