Proto-Oncogene c-Rel antibody
Rabbit anti Human proto-oncogene c-Rel antibody recognizes proto-oncogene c-Rel, also known as oncogene REL and avian reticuloendotheliosis viral oncogene homolog; REL.
Encoded by the REL gene, proto-oncogene c-Rel is a transcription factor that is a member of the Rel/NFKB family, which also includes RELA, RELB, NFKB1 and NFKB2 (MIM 164012). These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor (Belguise and Sonenshein, 2007) (PubMed 18037997).
Rabbit anti Human proto-oncogene c-Rel antibody detects a band of 69 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Encoded by the REL gene, proto-oncogene c-Rel is a transcription factor that is a member of the Rel/NFKB family, which also includes RELA, RELB, NFKB1 and NFKB2 (MIM 164012). These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor (Belguise and Sonenshein, 2007) (PubMed 18037997).
Rabbit anti Human proto-oncogene c-Rel antibody detects a band of 69 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Product Details
- Target Species
- Human
- Western Blotting
- Anti proto-oncogene c-Rel detects a band of approximately 69 kDa in Jurkat cell lysates
- Product Form
- Purified IgG - liquid
- Preparation
- Rabbit Ig fraction prepared by ammonium sulphate precipitation
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Proto-oncogene c-Rel-His fusion protein
Storage Information
- Storage
- Store undiluted at -20oC, avoiding repeated freeze thaw cycles.
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- Q04864
- Entrez Gene
- REL
- GO Terms
- GO:0005515 protein binding
- GO:0003677 DNA binding
- GO:0003700 sequence-specific DNA binding transcription factor activity
- GO:0005634 nucleus
- GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
- Regulatory
- For research purposes only
Applications of Proto-Oncogene c-Rel antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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