Rabbit anti presenilin-2 antibody recognizes presenilin-2. Presenilin-2 forms part of the gamma secratase complex responsible for the production of beta amyloid peptides. Presenilin-2 also modulates endoplasmic reticulum-mitochondria tethering.
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to presenilin-2 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
- Synthetic human presenilin-2
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
integral to plasma membrane
nuclear inner membrane
mitochondrial inner membrane
endoplasmic reticulum membrane
membrane protein ectodomain proteolysis
calcium ion transport
Notch signaling pathway
Notch receptor processing
induction of apoptosis by extracellular signals
apical plasma membrane
membrane protein intracellular domain proteolysis
amyloid precursor protein catabolic process
neuronal cell body
positive regulation of catalytic activity
nerve growth factor receptor signaling pathway
perinuclear region of cytoplasm
beta-amyloid metabolic process
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Presenilin-2 antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti presenilin-2 antibody detects a band of approximately 50 kDa in cell lysates and tissue lysates under reducing conditions
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Secondary Antibodies Available
Useful Reagents Available
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