Presenilin-1 antibody
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (presenilin-1 or presenilin-2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for Presenilin-1, the full-length nature of only some have been determined (provided by RefSeq, Aug 2008).
Rabbit anti Human presenilin-1 antibody detects a band of 55 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Product Details
- Target Species
- Human
- Western Blotting
- Anti presenilin-1 detects a band of approximately 55 kDa in Raji cell lysate
- Product Form
- Ig fraction - liquid
- Preparation
- Rabbit Ig fraction prepared by ammonium sulphate precipitation
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- KLH-conjugated synthetic peptide corresponding to aa 330-359 of human presenilin-1
Storage Information
- Storage
- Store undiluted at -20oC, avoiding repeated freeze thaw cycles
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P49768
- Entrez Gene
- PSEN1
- GO Terms
- GO:0000139 Golgi membrane
- GO:0000776 kinetochore
- GO:0004175 endopeptidase activity
- GO:0005887 integral to plasma membrane
- GO:0005262 calcium channel activity
- GO:0005640 nuclear outer membrane
- GO:0005743 mitochondrial inner membrane
- GO:0005765 lysosomal membrane
- GO:0005789 endoplasmic reticulum membrane
- GO:0005790 smooth endoplasmic reticulum
- GO:0005791 rough endoplasmic reticulum
- GO:0005813 centrosome
- GO:0005938 cell cortex
- GO:0006509 membrane protein ectodomain proteolysis
- GO:0006916 anti-apoptosis
- GO:0007219 Notch signaling pathway
- GO:0007220 Notch receptor processing
- GO:0008013 beta-catenin binding
- GO:0008624 induction of apoptosis by extracellular signals
- GO:0009986 cell surface
- GO:0016324 apical plasma membrane
- GO:0016337 cell-cell adhesion
- GO:0030018 Z disc
- GO:0030165 PDZ domain binding
- GO:0030424 axon
- GO:0030426 growth cone
- GO:0031293 membrane protein intracellular domain proteolysis
- GO:0031594 neuromuscular junction
- GO:0035253 ciliary rootlet
- GO:0042987 amyloid precursor protein catabolic process
- GO:0043025 neuronal cell body
- GO:0043198 dendritic shaft
- GO:0045121 membrane raft
- GO:0045296 cadherin binding
- GO:0048011 nerve growth factor receptor signaling pathway
- GO:0048471 perinuclear region of cytoplasm
- GO:0050435 beta-amyloid metabolic process
- GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis
- GO:0070765 gamma-secretase complex
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
- Regulatory
- For research purposes only
Applications of Presenilin-1 antibody
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
Secondary Antibodies Available
Description | Product Code | Applications | Pack Size | List Price | Quantity |
---|---|---|---|---|---|
Goat anti Rabbit IgG (H/L):HRP | STAR208P | WB | 2 ml |
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