Presenilin-1 antibody
Rabbit anti Human presenilin-1 antibody recognizes presenilin-1 also known as PSEN1.
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (presenilin-1 or presenilin-2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for Presenilin-1, the full-length nature of only some have been determined (provided by RefSeq, Aug 2008).
Rabbit anti Human presenilin-1 antibody detects a band of 55 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (presenilin-1 or presenilin-2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for Presenilin-1, the full-length nature of only some have been determined (provided by RefSeq, Aug 2008).
Rabbit anti Human presenilin-1 antibody detects a band of 55 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Product Details
- Target Species
- Human
- Western Blotting
- Anti presenilin-1 detects a band of approximately 55 kDa in Raji cell lysate
- Product Form
- Ig fraction - liquid
- Preparation
- Rabbit Ig fraction prepared by ammonium sulphate precipitation
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- KLH-conjugated synthetic peptide corresponding to aa 330-359 of human presenilin-1
Storage Information
- Storage
- Store undiluted at -20oC, avoiding repeated freeze thaw cycles
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P49768
- Entrez Gene
- PSEN1
- GO Terms
- GO:0000139 Golgi membrane
- GO:0000776 kinetochore
- GO:0004175 endopeptidase activity
- GO:0005887 integral to plasma membrane
- GO:0005262 calcium channel activity
- GO:0005640 nuclear outer membrane
- GO:0005743 mitochondrial inner membrane
- GO:0005765 lysosomal membrane
- GO:0005789 endoplasmic reticulum membrane
- GO:0005790 smooth endoplasmic reticulum
- GO:0005791 rough endoplasmic reticulum
- GO:0005813 centrosome
- GO:0005938 cell cortex
- GO:0006509 membrane protein ectodomain proteolysis
- GO:0006916 anti-apoptosis
- GO:0007219 Notch signaling pathway
- GO:0007220 Notch receptor processing
- GO:0008013 beta-catenin binding
- GO:0008624 induction of apoptosis by extracellular signals
- GO:0009986 cell surface
- GO:0016324 apical plasma membrane
- GO:0016337 cell-cell adhesion
- GO:0030018 Z disc
- GO:0030165 PDZ domain binding
- GO:0030424 axon
- GO:0030426 growth cone
- GO:0031293 membrane protein intracellular domain proteolysis
- GO:0031594 neuromuscular junction
- GO:0035253 ciliary rootlet
- GO:0042987 amyloid precursor protein catabolic process
- GO:0043025 neuronal cell body
- GO:0043198 dendritic shaft
- GO:0045121 membrane raft
- GO:0045296 cadherin binding
- GO:0048011 nerve growth factor receptor signaling pathway
- GO:0048471 perinuclear region of cytoplasm
- GO:0050435 beta-amyloid metabolic process
- GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis
- GO:0070765 gamma-secretase complex
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
- Regulatory
- For research purposes only
Applications of Presenilin-1 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Rabbit IgG (H/L):HRP | STAR208P | WB | 2 ml |
