Presenilin-1 antibody

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Rabbit anti Human Presenilin-1 (Loop)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
AHP667 C IP WB 0.1 ml
Rabbit anti Human presenilin antibody recognizes presenilin-1 (PSEN1), an integral membrane protein that is widely expressed, especially in brain tissue.

PSEN1 is an essential component of the gamma-secretase complex, along with APH-1 (APH-1A or APH-1B), PSEN2, Pen-2 (PEN2), and nicastrin (NCSTN). This endoprotease complex plays a vital role in the evolutionarily conserved Notch signaling pathway, by catalyzing the intramembrane S3 cleavage of ligand-activated Notch receptor proteins (Notch1-4), resulting in the generation and release of an activated NICD fragment, which then translocates to the nucleus and activates the transcription of downstream effector genes.

Mutations of presenilin-1 are associated with early onset Alzheimer's disease.

Product Details

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Monkey
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Serum - liquid
Antiserum Preparation
Antisera to presenilin-1 were raised by repeated immunisations of rabbits with highly purified antigen.
Preservative Stabilisers
0.02%Sodium Azide

Storage Information

Storage
Store at +4oC or at -20oC if preferred.

This product should be stored undiluted.

Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
18 months from date of despatch.

More Information

UniProt
P49768 Related reagents
Entrez Gene
PSEN1 Related reagents
GO Terms
GO:0000139 Golgi membrane
GO:0000776 kinetochore
GO:0004175 endopeptidase activity
GO:0005887 integral to plasma membrane
GO:0005262 calcium channel activity
GO:0005640 nuclear outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005765 lysosomal membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005790 smooth endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0005813 centrosome
GO:0005938 cell cortex
GO:0006509 membrane protein ectodomain proteolysis
GO:0006916 anti-apoptosis
GO:0007219 Notch signaling pathway
GO:0007220 Notch receptor processing
GO:0008013 beta-catenin binding
GO:0008624 induction of apoptosis by extracellular signals
GO:0009986 cell surface
GO:0016324 apical plasma membrane
GO:0016337 cell-cell adhesion
GO:0030018 Z disc
GO:0030165 PDZ domain binding
GO:0030424 axon
GO:0030426 growth cone
GO:0031293 membrane protein intracellular domain proteolysis
GO:0031594 neuromuscular junction
GO:0035253 ciliary rootlet
GO:0042987 amyloid precursor protein catabolic process
GO:0043025 neuronal cell body
GO:0043198 dendritic shaft
GO:0045121 membrane raft
GO:0045296 cadherin binding
GO:0048011 nerve growth factor receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0050435 beta-amyloid metabolic process
GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis
GO:0070765 gamma-secretase complex
Regulatory
For research purposes only

Applications of Presenilin-1 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Frozen
Immunoprecipitation
Western Blotting 1/500 1/1000
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Sheep anti Rabbit IgG:Biotin 2AB02B 1 ml C E P WB
Goat anti Rabbit IgG (Fc):Biotin STAR121B 1 mg E WB
Goat anti Rabbit IgG (Fc):FITC STAR121F 1 mg F
Goat anti Rabbit IgG (Fc):HRP STAR121P 1 mg E WB
Goat anti Rabbit IgG (H/L):HRP STAR124P 1 mg C E WB
Sheep anti Rabbit IgG:FITC STAR34B 1 mg C F
Sheep anti Rabbit IgG:RPE STAR35A 1 ml F
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA 0.1 mg F IF WB
Sheep anti Rabbit IgG:DyLight®549 STAR36D549GA 0.1 mg F IF
Sheep anti Rabbit IgG:DyLight®649 STAR36D649GA 0.1 mg F IF
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA 0.1 mg F IF WB
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA 0.1 mg F IF WB

Useful Reagents Available

Description Product Code Pack Size Applications List Price Quantity
TidyBlot™ Western Blot Detection Reagent:HRP STAR209P 0.5 ml WB*