Rabbit anti Human presenilin antibody recognizes presenilin-1 (PSEN1), an integral membrane protein that is widely expressed, especially in brain tissue.
PSEN1 is an essential component of the gamma-secretase complex, along with APH-1 (APH-1A or APH-1B), PSEN2, Pen-2 (PEN2), and nicastrin (NCSTN). This endoprotease complex plays a vital role in the evolutionarily conserved Notch signaling pathway, by catalyzing the intramembrane S3 cleavage of ligand-activated Notch receptor proteins (Notch1-4), resulting in the generation and release of an activated NICD fragment, which then translocates to the nucleus and activates the transcription of downstream effector genes.
Mutations of presenilin-1 are associated with early onset Alzheimer's disease.
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Serum - liquid
- Antiserum Preparation
- Antisera to presenilin-1 were raised by repeated immunisations of rabbits with highly purified antigen.
- Preservative Stabilisers
- Store at +4oC or at -20oC if preferred.
This product should be stored undiluted.
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
integral to plasma membrane
calcium channel activity
nuclear outer membrane
mitochondrial inner membrane
endoplasmic reticulum membrane
smooth endoplasmic reticulum
rough endoplasmic reticulum
membrane protein ectodomain proteolysis
Notch signaling pathway
Notch receptor processing
induction of apoptosis by extracellular signals
apical plasma membrane
PDZ domain binding
membrane protein intracellular domain proteolysis
amyloid precursor protein catabolic process
neuronal cell body
nerve growth factor receptor signaling pathway
perinuclear region of cytoplasm
beta-amyloid metabolic process
smooth endoplasmic reticulum calcium ion homeostasis
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Presenilin-1 antibody
|Immunohistology - Frozen
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
Useful Reagents Available