Rabbit anti presenilin-1 antibody recognizes presenilin-1. Presenilin-1 forms part of the gamma secratase complex. Presenilin-1 has roles in the production of beta amyloid as well as Notch and Wnt signaling pathways.
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
||Expected from Sequence
||Expected from Sequence
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to presenilin-1 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
- Recombinant human presenilin-1
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
integral to plasma membrane
calcium channel activity
nuclear outer membrane
mitochondrial inner membrane
endoplasmic reticulum membrane
smooth endoplasmic reticulum
rough endoplasmic reticulum
membrane protein ectodomain proteolysis
Notch signaling pathway
Notch receptor processing
induction of apoptosis by extracellular signals
apical plasma membrane
PDZ domain binding
membrane protein intracellular domain proteolysis
amyloid precursor protein catabolic process
neuronal cell body
nerve growth factor receptor signaling pathway
perinuclear region of cytoplasm
beta-amyloid metabolic process
smooth endoplasmic reticulum calcium ion homeostasis
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Presenilin-1 antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti presenilin-1 antibody detects a band of approximately 53 kDa in human kidney tissue under reducing conditions
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Secondary Antibodies Available
Useful Reagents Available
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