Presenilin-1 antibody
Rabbit anti presenilin-1 antibody recognizes presenilin-1. Presenilin-1 forms part of the gamma secratase complex. Presenilin-1 has roles in the production of beta amyloid as well as Notch and Wnt signaling pathways.
Product Details
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Expected from Sequence Rat Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to presenilin-1 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
50% Glycerol - Immunogen
- Recombinant human presenilin-1
Storage Information
- Storage
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P49768
- Entrez Gene
- PSEN1
- GO Terms
- GO:0000139 Golgi membrane
- GO:0000776 kinetochore
- GO:0004175 endopeptidase activity
- GO:0005887 integral to plasma membrane
- GO:0005262 calcium channel activity
- GO:0005640 nuclear outer membrane
- GO:0005743 mitochondrial inner membrane
- GO:0005765 lysosomal membrane
- GO:0005789 endoplasmic reticulum membrane
- GO:0005790 smooth endoplasmic reticulum
- GO:0005791 rough endoplasmic reticulum
- GO:0005813 centrosome
- GO:0005938 cell cortex
- GO:0006509 membrane protein ectodomain proteolysis
- GO:0006916 anti-apoptosis
- GO:0007219 Notch signaling pathway
- GO:0007220 Notch receptor processing
- GO:0008013 beta-catenin binding
- GO:0008624 induction of apoptosis by extracellular signals
- GO:0009986 cell surface
- GO:0016324 apical plasma membrane
- GO:0016337 cell-cell adhesion
- GO:0030018 Z disc
- GO:0030165 PDZ domain binding
- GO:0030424 axon
- GO:0030426 growth cone
- GO:0031293 membrane protein intracellular domain proteolysis
- GO:0031594 neuromuscular junction
- GO:0035253 ciliary rootlet
- GO:0042987 amyloid precursor protein catabolic process
- GO:0043025 neuronal cell body
- GO:0043198 dendritic shaft
- GO:0045121 membrane raft
- GO:0045296 cadherin binding
- GO:0048011 nerve growth factor receptor signaling pathway
- GO:0048471 perinuclear region of cytoplasm
- GO:0050435 beta-amyloid metabolic process
- GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis
- GO:0070765 gamma-secretase complex
- Regulatory
- For research purposes only
Applications of Presenilin-1 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/500 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti presenilin-1 antibody detects a band of approximately 53 kDa in human kidney tissue under reducing conditions
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
|
|
| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
|
|
| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
|
|
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
|
|
| Sheep anti Rabbit IgG:FITC | STAR34B | C F | 1 mg |
|
|
| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
|
Useful Reagents Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| TidyBlot Western Blot Detection Reagent:HRP | STAR209P | WB* | 0.5 ml |
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