PI-3 Kinase p110 Subunit Alpha antibody
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WB ResetGoat anti Human PI-3 Kinase p110 Subunit Alpha
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- PI-3 Kinase p110 Subunit Alpha
Antibody Quality and 
Unrivaled 
| Goat anti Human PI-3 kinase p110 subunit alpha antibody recognizes human PI3-kinase p110 subunit alpha (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha), otherwise known as PIK3CA, a member of the PI3/PI4-kinase family of lipid kinases, implicated in the regulation of signal transduction during cell growth. PI3-kinase is a heterodimer consisting of a p85 regulatory subunit and a p110 catalytic subunit, which itself is divided into isoforms p110alpha, p110beta, p110delta and p110gamma. Mutations in the PIK3CA gene are associated with breast, ovarian and colorectal cancers (CRC).http://www.omim.org/entry/114500 Colorectal cancer is a heterogeneous disease that is common in both men and women. characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum (Vehlo et al. 2005). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Expected from Sequence Rat Expected from Sequence Dog Expected from Sequence Bovine Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to human p110alpha was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
- Buffer Solution
- TRIS buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide (NaN3)
0.5% Bovine Serum Albumin - Immunogen
- Synthetic peptide C-HQWLKDKNKGEIYD from the internal region of human PI3-kinase p110 subunit alpha (NP_006209.2).
- Approx. Protein Concentrations
- IgG concentration 0.5mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
1/128000 | |
| Immunohistology - Paraffin | |
2.0 | 3.0ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- Human cerebral cortex
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- Synonyms
- PIK3CA
- RRID
- AB_2299726
- UniProt
- P42336
- Entrez Gene
- PIK3CA
- GO Terms
- GO:0005524 ATP binding
- GO:0007173 epidermal growth factor receptor signaling pathway
- GO:0008286 insulin receptor signaling pathway
- GO:0008543 fibroblast growth factor receptor signaling pathway
- GO:0016303 1-phosphatidylinositol-3-kinase activity
- GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
- GO:0048015 phosphatidylinositol-mediated signaling
- GO:0030168 platelet activation
- GO:0031295 T cell costimulation
- View More GO Terms
- GO:0048011 nerve growth factor receptor signaling pathway
- GO:0050852 T cell receptor signaling pathway
- GO:0050900 leukocyte migration
View more products with PI-3 KINASE specificity
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