Peroxiredoxin 3 antibody
Rabbit anti Human peroxiredoxin 3 antibody recognizes peroxiredoxin 3 also known as antioxidant protein 1 and protein MER5 homolog.
Peroxiredoxin 3 is a protein with antioxidant function and is localized in the mitochondrion. The PRDX3 gene shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase. Expression of PRDX3 product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for PRDX3 (provided by RefSeq, Jul 2008).
Rabbit anti Human peroxiredoxin 3 antibody detects a band of 23 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Peroxiredoxin 3 is a protein with antioxidant function and is localized in the mitochondrion. The PRDX3 gene shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase. Expression of PRDX3 product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for PRDX3 (provided by RefSeq, Jul 2008).
Rabbit anti Human peroxiredoxin 3 antibody detects a band of 23 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Product Details
- Target Species
- Human
- Western Blotting
- Anti peroxiredoxin 3 detects a band of approximately 23 kDa in HEK293 cell lysate
- Product Form
- Purified IgG - liquid
- Preparation
- Rabbit polyclonal antibody purified by affinity chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- KLH-conjugated synthetic peptide corresponding to aa 229-262 of human peroxiredoxin 3
Storage Information
- Storage
- Store undiluted at -20oC, avoiding repeated freeze thaw cycles
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P30048
- Entrez Gene
- PRDX3
- GO Terms
- GO:0005739 mitochondrion
- GO:0004601 peroxidase activity
- GO:0005769 early endosome
- GO:0055114 oxidation-reduction process
- GO:0045454 cell redox homeostasis
- GO:0007005 mitochondrion organization
- GO:0008022 protein C-terminus binding
- GO:0008284 positive regulation of cell proliferation
- GO:0008785 alkyl hydroperoxide reductase activity
- GO:0019901 protein kinase binding
- GO:0030099 myeloid cell differentiation
- GO:0032496 response to lipopolysaccharide
- GO:0033673 negative regulation of kinase activity
- GO:0042744 hydrogen peroxide catabolic process
- GO:0043027 caspase inhibitor activity
- GO:0051092 positive regulation of NF-kappaB transcription factor activity
- GO:0051881 regulation of mitochondrial membrane potential
- GO:0051920 peroxiredoxin activity
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
- Regulatory
- For research purposes only
Applications of Peroxiredoxin 3 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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|---|---|---|---|---|---|
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