Rabbit anti P90RSK1 antibody
recognizes recognizes ribosomal protein S6 kinase alpha-1, also known as p90S6K, MAPK-activated protein kinase 1a, MAPKAPK-1a and RSK-1. It belongs to the RSK (ribosomal S6 kinase) family of serine/threonine kinases (Fisher and Blenis 1996
). It is a downstream effector of Ras/ERK signalling pathway (Casalvieri et al. 2017
). It directly phosphorylates IkappaBbeta and activates NF-kappaB (Xu et al. 2006
). It has been reported to phosphorylate CREB on Ser133 (Cho et al. 2011
). RSK also promotes mTOR signaling and translation (Shahbazian et al. 2006
). Expression and activity of RSK1 promotes tumor growth and survival (Casalvieri et al. 2017).
- Target Species
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to P90RSK1 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
- A synthetic peptide corresponding to a sequence from amino acid 600 to the C-terminus of human P90RSK1
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
magnesium ion binding
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
protein serine/threonine kinase activity
Toll signaling pathway
toll-like receptor 1 signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
innate immune response
nerve growth factor receptor signaling pathway
stress-activated MAPK cascade
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of P90RSK1 antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti P90RSK1 antibody detects a band of approximately 90 kDa in various cell and tissue lysates under reducing conditions
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Secondary Antibodies Available